Vps53 - VPS53 GARP complex subunit Gene

Also Known as Hccs1; 2010002A08Rik; 2310040I21Rik; 3100002B05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68299

Summary

Predicted to be involved in endocytic recycling and retrograde transport, endosome to Golgi. Predicted to act upstream of or within lysosomal transport. Predicted to be located in several cellular components, including perinuclear region of cytoplasm; recycling endosome; and trans-Golgi network. Predicted to be part of EARP complex and GARP complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2E. Orthologous to human VPS53 (VPS53 subunit of GARP complex). [provided by Alliance of Genome Resources, Apr 2022]

Vps53 Products (2)

mRNA Protein Name
NM_001364738.1 NP_001351667.1 vacuolar protein sorting-associated protein 53 homolog isoform 2
NM_026664.4 NP_080940.2 vacuolar protein sorting-associated protein 53 homolog isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in protein targeting to lysosome IMP
IMP: Inferred from mutant phenotype
28658628 MGI
involved in vesicle-mediated cholesterol transport IMP
IMP: Inferred from mutant phenotype
28658628 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 53 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15698 VPS53 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vps53 NCBI NCBI:55275