Ccdc88c - coiled-coil domain containing 88C Gene

Also Known as Daple; mKIAA1509; 0610010D24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68339

Summary

Enables PDZ domain binding activity; identical protein binding activity; and protein self-association. Involved in protein destabilization and regulation of protein phosphorylation. Predicted to be located in cell junction. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; long bone; and reproductive system. Human ortholog(s) of this gene implicated in hydrocephalus and spinocerebellar ataxia type 40. Orthologous to human CCDC88C (coiled-coil domain containing 88C). [provided by Alliance of Genome Resources, Apr 2022]

Ccdc88c Products (2)

mRNA	Protein	Name
NM_001362342.1	NP_001349271.1	protein Daple isoform 2
NM_026681.5	NP_080957.2	protein Daple isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	14750955	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	33929515	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14750955	MGI
enables protein dimerization activity	IDA IDA: Inferred from direct assay	33929515	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	33929515	MGI
acts upstream of or within cilium movement	IMP IMP: Inferred from mutant phenotype	33929515	MGI
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	33929515	MGI
acts upstream of or within microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	33929515	MGI
acts upstream of or within mucociliary clearance	IMP IMP: Inferred from mutant phenotype	33929515	MGI
acts upstream of or within negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	33929515	MGI
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	14750955	MGI
acts upstream of or within respiratory basal cell differentiation	IMP IMP: Inferred from mutant phenotype	33929515	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in apical junction complex	IDA IDA: Inferred from direct assay	33929515	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein Daple	DVL-binding protein DAPLE coiled-coil domain-containing protein 88C dvl-associating protein with a high frequency of leucine residues

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02063	CCDC88C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccdc88c	NCBI	NCBI:440193