Kcnc4 - potassium voltage-gated channel subfamily C member 4 Gene

Rattus norvegicus

Gene ID: 684516 | Gene type: protein coding

About Kcnc4

Summary

Enables voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in forebrain development; negative regulation of neuronal action potential; and negative regulation of sensory perception of pain. Located in several cellular components, including Golgi apparatus; dendrite; and neuronal cell body. Is active in calyx of Held; glutamatergic synapse; and glycinergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with synaptic vesicle. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc4 Products(1)

mRNA	Protein	Name
NM_001122776.1	NP_001116248.1	potassium voltage-gated channel subfamily C member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21943417	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	12592408	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	12592408	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	12592408	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	12592408	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	1840526	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in negative regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	18048010	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	22473424	RGD
is active in calyx of Held	IDA IDA: Inferred from direct assay	14614103	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21943416	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15207333	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14614103	RGD
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	15207333	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15207333	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	15207333	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14614103	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15207333	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily C member 4

potassium channel, voltage gated Shaw-related subfamily C, member 4	potassium voltage gated channel, Shaw-related subfamily, member 4
potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3)	raw3
volt

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07111	KCNC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnc4	NCBI	NCBI:3749

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