Kcnc4 - potassium voltage-gated channel subfamily C member 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 684516

Summary

Enables voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in forebrain development; negative regulation of neuronal action potential; and negative regulation of sensory perception of pain. Located in several cellular components, including Golgi apparatus; dendrite; and neuronal cell body. Is active in calyx of Held; glutamatergic synapse; and glycinergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with synaptic vesicle. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc4 Products (1)

mRNA Protein Name
NM_001122776.1 NP_001116248.1 potassium voltage-gated channel subfamily C member 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21943417 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
12592408 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
12592408 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
12592408 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
12592408 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
1840526 RGD
Biological Process GO Annotation Evidence References Source
involved in axon development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in negative regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
18048010 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
22473424 RGD
is active in calyx of Held IDA
IDA: Inferred from direct assay
14614103 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21943416 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15207333 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14614103 RGD
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
15207333 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15207333 RGD
located in postsynapse IDA
IDA: Inferred from direct assay
15207333 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14614103 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14614103 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
15207333 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily C member 4

  • potassium channel, voltage gated Shaw-related subfamily C, member 4

  • potassium voltage gated channel, Shaw-related subfamily, member 4

  • potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3)

  • raw3

  • volt

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07111 KCNC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnc4 NCBI NCBI:3749