Nsmce2 - NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Gene

Mus musculus

Also known as 1110014D18Rik

Gene ID: 68501 | Gene type: protein coding

About Nsmce2

Summary

Predicted to enable SUMO Ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to act upstream of or within DNA recombination; DNA repair; and cell division. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in brain; spermatocyte; and testis. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nsmce2 Products(3)

mRNA	Protein	Name
NM_001164604.1	NP_001158076.1	E3 SUMO-protein ligase NSE2 isoform 2
NM_001374768.1	NP_001361697.1	E3 SUMO-protein ligase NSE2 isoform 3
NM_026746.3	NP_081022.2	E3 SUMO-protein ligase NSE2 isoform 1

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase NSE2

E3 SUMO-protein transferase NSE2	MMS21 homolog
non-SMC element 2 homolog (MMS21, S. cerevisiae)	non-structural maintenance of chromosomes element 2 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09598	NSMCE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nsmce2	NCBI	NCBI:286053

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