IQSEC1 - Iqsec1 IQ motif and Sec7 domain ArfGEF 1 Gene
Species: Rattus norvegicus
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in nucleolus. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Apr 2022]
IQSEC1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001408959.1 | NP_001395888.1 | IQ motif and SEC7 domain-containing protein 1 isoform 1 |
| NM_001408960.1 | NP_001395889.1 | IQ motif and SEC7 domain-containing protein 1 isoform 2 |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of synapse assembly |
IMP
IMP: Inferred from mutant phenotype
|
26884337 | RGD |
| involved in regulation of ARF protein signal transduction |
IGI
IGI: Inferred from genetic interaction
|
26884337 | RGD |
| involved in regulation of postsynaptic neurotransmitter receptor internalization |
IMP
IMP: Inferred from mutant phenotype
|
26884337 | RGD |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
IQ motif and SEC7 domain-containing protein 1 |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS06888 | IQSEC1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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