2. Gene
  3. IQSEC1 - Iqsec1 IQ motif and Sec7 domain ArfGEF 1 Gene

IQSEC1 - Iqsec1 IQ motif and Sec7 domain ArfGEF 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 686590 | Gene type: protein coding

About IQSEC1

Summary

Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in nucleolus. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Apr 2022]

IQSEC1 Products(2)

mRNA Protein Name
NM_001408959.1 NP_001395888.1 IQ motif and SEC7 domain-containing protein 1 isoform 1
NM_001408960.1 NP_001395889.1 IQ motif and SEC7 domain-containing protein 1 isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
26884337 RGD
involved in regulation of ARF protein signal transduction IGI
IGI: Inferred from genetic interaction
26884337 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
26884337 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

IQ motif and SEC7 domain-containing protein 1

IQ motif and Sec7 domain 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06888 IQSEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens IQSEC1 NCBI NCBI:9922