2. Gene
  3. Carmil1 - capping protein regulator and myosin 1 linker 1 Gene

Carmil1 - capping protein regulator and myosin 1 linker 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CARMIL; CARML1; Lrrc16; Lrrc16a; D130057M20; 1110037D04Rik

Gene ID: 68732 | Gene type: protein coding

About Carmil1

Summary

Involved in several processes, including positive regulation of lamellipodium organization; positive regulation of substrate adhesion-dependent cell spreading; and positive regulation of supramolecular fiber organization. Located in lamellipodium. Part of filamentous actin. Is expressed in palatal shelf; skeleton; telencephalon; and vibrissa. Orthologous to human CARMIL1 (capping protein regulator and Myosin 1 linker 1). [provided by Alliance of Genome Resources, Apr 2022]

Carmil1 Products(3)

mRNA Protein Name
NM_001311122.1 NP_001298051.1 F-actin-uncapping protein LRRC16A isoform 2
NM_001384122.1 NP_001371051.1 F-actin-uncapping protein LRRC16A isoform 3
NM_026825.3 NP_081101.3 F-actin-uncapping protein LRRC16A isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
16054028 MGI
Biological Process GO Annotation Evidence Reference Source
involved in barbed-end actin filament uncapping IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in negative regulation of barbed-end actin filament capping IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of lamellipodium organization IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
16054028 MGI
Cellular Component GO Annotation Evidence Reference Source
part of filamentous actin IDA
IDA: Inferred from direct assay
16054028 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
16054028 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-actin-uncapping protein LRRC16A

CARMIL homolog

capping protein regulator and myosin 1 linker protein 1

capping protein, Arp2/3 and myosin-I linker homolog 1

capping protein, Arp2/3 and myosin-I linker protein 1

leucine rich repeat containing 16

leucine rich repeat containing 16A

l

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01929 CARMIL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Carmil1 NCBI NCBI:55604