Carmil1 - capping protein regulator and myosin 1 linker 1 Gene

Also Known as CARMIL; CARML1; Lrrc16; Lrrc16a; D130057M20; 1110037D04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68732

Summary

Involved in several processes, including positive regulation of lamellipodium organization; positive regulation of substrate adhesion-dependent cell spreading; and positive regulation of supramolecular fiber organization. Located in lamellipodium. Part of filamentous actin. Is expressed in palatal shelf; skeleton; telencephalon; and vibrissa. Orthologous to human CARMIL1 (capping protein regulator and Myosin 1 linker 1). [provided by Alliance of Genome Resources, Apr 2022]

Carmil1 Products (3)

mRNA Protein Name
NM_001311122.1 NP_001298051.1 F-actin-uncapping protein LRRC16A isoform 2
NM_001384122.1 NP_001371051.1 F-actin-uncapping protein LRRC16A isoform 3
NM_026825.3 NP_081101.3 F-actin-uncapping protein LRRC16A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
16054028 MGI
Biological Process GO Annotation Evidence References Source
involved in barbed-end actin filament uncapping IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in negative regulation of barbed-end actin filament capping IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of lamellipodium organization IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
16054028 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
16054028 MGI
Cellular Component GO Annotation Evidence References Source
part of filamentous actin IDA
IDA: Inferred from direct assay
16054028 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
16054028 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-actin-uncapping protein LRRC16A

  • CARMIL homolog

  • capping protein regulator and myosin 1 linker protein 1

  • capping protein, Arp2/3 and myosin-I linker homolog 1

  • capping protein, Arp2/3 and myosin-I linker protein 1

  • leucine rich repeat containing 16

  • leucine rich repeat containing 16A

  • l

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01929 CARMIL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Carmil1 NCBI NCBI:55604