Foxk2 - forkhead box K2 Gene

Also Known as ILF; Ilf1; 1110054H05Rik; 5730434B08Rik; 6230415M23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68837

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; genitourinary system; and nervous system. Orthologous to human FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Apr 2022]

Foxk2 Products (2)

mRNA Protein Name
NM_001080932.3 NP_001074401.2 forkhead box protein K2 isoform 1
NM_001363033.1 NP_001349962.1 forkhead box protein K2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
29861159 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
25402684 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25402684 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of canonical glycolysis IDA
IDA: Inferred from direct assay
30700909 MGI
involved in intracellular glucose homeostasis IDA
IDA: Inferred from direct assay
29861159 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
25402684 MGI
involved in negative regulation of autophagy IDA
IDA: Inferred from direct assay
25402684 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
29861159 MGI
involved in regulation of glucose metabolic process IDA
IDA: Inferred from direct assay
29861159 MGI
involved in response to starvation IDA
IDA: Inferred from direct assay
25402684 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25402684 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16376864 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein K2

  • cellular transcription factor ILF-1

  • interleukin enhancer-binding factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05060 FOXK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxk2 NCBI NCBI:3607