2. Gene
  3. Dnai1 - dynein axonemal intermediate chain 1 Gene

Dnai1 - dynein axonemal intermediate chain 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dnaic1; b2b1526Clo; 1110066F04Rik

Gene ID: 68922 | Gene type: protein coding

About Dnai1

Summary

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in Insulin Receptor signaling pathway. Acts upstream of or within determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and heart development. Located in 9+2 motile cilium; centrosome; and cytoplasm. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome; primary ciliary dyskinesia 1; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnai1 Products(1)

mRNA Protein Name
NM_175138.4 NP_780347.2 dynein axonemal intermediate chain 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28057765 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
20498047 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
28057765 MGI
Cellular Component GO Annotation Evidence Reference Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
23525783 MGI
located in centrosome IDA
IDA: Inferred from direct assay
28057765 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
28057765 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal intermediate chain 1

dynein intermediate chain 1, axonemal

axonemal dynein intermediate chain 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03855 DNAI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnai1 NCBI NCBI:27019