Dnai1 - dynein axonemal intermediate chain 1 Gene

Also Known as Dnaic1; b2b1526Clo; 1110066F04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68922

Summary

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in Insulin Receptor signaling pathway. Acts upstream of or within determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and heart development. Located in 9+2 motile cilium; centrosome; and cytoplasm. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome; primary ciliary dyskinesia 1; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnai1 Products (1)

mRNA Protein Name
NM_175138.4 NP_780347.2 dynein axonemal intermediate chain 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28057765 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
20498047 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
28057765 MGI
Cellular Component GO Annotation Evidence References Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
23525783 MGI
located in centrosome IDA
IDA: Inferred from direct assay
28057765 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
28057765 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal intermediate chain 1

dynein intermediate chain 1, axonemal

  • axonemal dynein intermediate chain 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03855 DNAI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnai1 NCBI NCBI:27019