Ctc1 - CTS telomere maintenance complex component 1 Gene

Also Known as AAF132; AAF-132; 1500010J02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68964

Summary

Enables single-stranded DNA binding activity. Involved in positive regulation of DNA replication. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; replicative senescence; and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region and nucleus. Part of CST complex. Is expressed in genitourinary system; mesonephric tubule; mesonephros; and nephric duct, metanephric portion. Orthologous to human CTC1 (CST telomere replication complex component 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctc1 Products (4)

mRNA	Protein	Name
NM_001013256.2	NP_001013274.2	CST complex subunit CTC1 isoform a
NM_001143790.1	NP_001137262.1	CST complex subunit CTC1 isoform c
NM_001281464.1	NP_001268393.1	CST complex subunit CTC1 isoform d
NM_001281465.1	NP_001268394.1	CST complex subunit CTC1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19119139	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	19119139	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within bone marrow development	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	22531781	MGI
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	19119139	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within replicative senescence	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	22531781	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of CST complex	IDA IDA: Inferred from direct assay	19854130	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	19854130	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19119139	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CST complex subunit CTC1	alpha accessory factor 132 alpha-accessory factor of 132 kDa conserved telomere maintenance component 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03286	CTC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W392413	Glutathione monoethyl ester	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctc1	NCBI	NCBI:80169