Kdf1 - keratinocyte differentiation factor 1 Gene

Also Known as 1810019J16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69073

Summary

Involved in several processes, including positive regulation of epidermal cell differentiation; regulation of epidermal cell division; and skin development. Acts upstream of or within keratinocyte development and negative regulation of keratinocyte proliferation. Located in cell cortex; cell junction; and cell leading edge. Is expressed in several structures, including alimentary system; choroid plexus; lower urinary tract; olfactory epithelium; and pituitary gland. Human ortholog(s) of this gene implicated in ectodermal dysplasia 12. Orthologous to human KDF1 (keratinocyte differentiation factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Kdf1 Products (2)

mRNA Protein Name
NM_001083916.1 NP_001077385.1 keratinocyte differentiation factor 1
NM_133707.2 NP_598468.2 keratinocyte differentiation factor 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in developmental growth IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of or within keratinocyte development IGI
IGI: Inferred from genetic interaction
24075906 MGI
acts upstream of or within keratinocyte development IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
24075906 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in limb epidermis development IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
24075906 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
24075906 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in positive regulation of epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in regulation of epidermal cell division IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
24075906 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
24075906 MGI
located in cell junction IDA
IDA: Inferred from direct assay
24075906 MGI
located in cell leading edge IDA
IDA: Inferred from direct assay
24075906 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24075906 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratinocyte differentiation factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07204 KDF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdf1 NCBI NCBI:126695