Camsap3 - calmodulin regulated spectrin-associated protein family, member 3 Gene

Also Known as Nezha; Kiaa1543; 2310057J16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69697

Summary

Enables microtubule minus-end binding activity. Involved in several processes, including establishment of epithelial cell apical/basal polarity; establishment or maintenance of microtubule Cytoskeleton polarity; and regulation of microtubule polymerization. Acts upstream of or within in utero embryonic development. Located in axoneme; ciliary basal body; and motile cilium. Colocalizes with microtubule minus-end. Is expressed in brain and lung epithelium. Orthologous to human CAMSAP3 (Calmodulin regulated spectrin associated protein family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Camsap3 Products (16)

mRNA Protein Name
NM_001163749.1 NP_001157221.1 calmodulin-regulated spectrin-associated protein 3 isoform 1
NM_001347111.1 NP_001334040.1 calmodulin-regulated spectrin-associated protein 3 isoform 3
NM_001347112.1 NP_001334041.1 calmodulin-regulated spectrin-associated protein 3 isoform 4
NM_001347113.1 NP_001334042.1 calmodulin-regulated spectrin-associated protein 3 isoform 5
NM_001363239.1 NP_001350168.1 calmodulin-regulated spectrin-associated protein 3 isoform 6
NM_001363240.1 NP_001350169.1 calmodulin-regulated spectrin-associated protein 3 isoform 7
NM_001363241.1 NP_001350170.1 calmodulin-regulated spectrin-associated protein 3 isoform 8
NM_001363242.1 NP_001350171.1 calmodulin-regulated spectrin-associated protein 3 isoform 9
NM_001363243.1 NP_001350172.1 calmodulin-regulated spectrin-associated protein 3 isoform 10
NM_001363244.1 NP_001350173.1 calmodulin-regulated spectrin-associated protein 3 isoform 11
NM_001363245.1 NP_001350174.1 calmodulin-regulated spectrin-associated protein 3 isoform 12
NM_001363246.1 NP_001350175.1 calmodulin-regulated spectrin-associated protein 3 isoform 13
NM_001363247.1 NP_001350176.1 calmodulin-regulated spectrin-associated protein 3 isoform 14
NM_001363248.1 NP_001350177.1 calmodulin-regulated spectrin-associated protein 3 isoform 15
NM_001363249.1 NP_001350178.1 calmodulin-regulated spectrin-associated protein 3 isoform 16
NM_027171.3 NP_081447.2 calmodulin-regulated spectrin-associated protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule minus-end binding IDA
IDA: Inferred from direct assay
23169647 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23169647 MGI
Biological Process GO Annotation Evidence References Source
involved in cilium movement IMP
IMP: Inferred from mutant phenotype
32482850 MGI
involved in embryo development ending in birth or egg hatching IDA
IDA: Inferred from direct assay
28860385 MGI
involved in establishment of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
26715742 MGI
involved in establishment or maintenance of microtubule cytoskeleton polarity IMP
IMP: Inferred from mutant phenotype
26715742 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
involved in microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
24706919 MGI
involved in protein transport along microtubule IDA
IDA: Inferred from direct assay
28860385 MGI
involved in regulation of microtubule polymerization IDA
IDA: Inferred from direct assay
24706919 MGI
involved in regulation of organelle organization IGI
IGI: Inferred from genetic interaction
23169647 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
32482850 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
32482850 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
32482850 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
23169647 MGI
colocalizes with microtubule minus-end IDA
IDA: Inferred from direct assay
24706919 MGI
located in microtubule minus-end IDA
IDA: Inferred from direct assay
23169647 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
32482850 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calmodulin-regulated spectrin-associated protein 3

  • marshalin

  • protein Nezha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01873 CAMSAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Camsap3 NCBI NCBI:57662