Fuz - fuzzy planar cell polarity protein Gene

Mus musculus

Also known as b2b1273Clo; 2600013E07Rik

Gene ID: 70300 | Gene type: protein coding

About Fuz

Summary

Involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and positive regulation of protein processing. Predicted to be located in cell projection; cytoplasm; and Cytoskeleton. Is expressed in several structures, including central nervous system; neural ectoderm; and notochord. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]

Fuz Products(9)

mRNA	Protein	Name
NM_001403450.1	NP_001390379.1	protein fuzzy homolog isoform 1
NM_001403451.1	NP_001390380.1	protein fuzzy homolog isoform 3
NM_001403452.1	NP_001390381.1	protein fuzzy homolog isoform 4
NM_001403453.1	NP_001390382.1	protein fuzzy homolog isoform 5
NM_001403454.1	NP_001390383.1	protein fuzzy homolog isoform 6
NM_001403455.1	NP_001390384.1	protein fuzzy homolog isoform 7
NM_001403456.1	NP_001390385.1	protein fuzzy homolog isoform 8
NM_001403457.1	NP_001390386.1	protein fuzzy homolog isoform 9
NM_027376.4	NP_081652.2	protein fuzzy homolog isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	35427153	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27158779	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	19877275	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	19877275	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	19767740	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	19767740	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	19877275	MGI
acts upstream of or within embryonic neurocranium morphogenesis	IGI IGI: Inferred from genetic interaction	27395007	MGI
acts upstream of or within embryonic neurocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	27395007	MGI
involved in embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	19767740	MGI
involved in establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	19767740	MGI
involved in hair follicle development	IMP IMP: Inferred from mutant phenotype	20962855	MGI
acts upstream of or within larynx morphogenesis	IGI IGI: Inferred from genetic interaction	28177282	MGI
acts upstream of or within larynx morphogenesis	IMP IMP: Inferred from mutant phenotype	28177282	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21935430	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21935430	MGI
involved in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	IMP IMP: Inferred from mutant phenotype	23806618	MGI
involved in negative regulation of neural crest formation	IMP IMP: Inferred from mutant phenotype	23806618	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	19877275	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	19767740	MGI
involved in non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21935430	MGI
involved in positive regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	21935430	MGI
acts upstream of or within positive regulation of protein processing	IMP IMP: Inferred from mutant phenotype	19877275	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19877275	MGI
involved in regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19767740	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	27158779	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	19877275	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	21761479	MGI
acts upstream of or within tongue morphogenesis	IMP IMP: Inferred from mutant phenotype	27158779	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein fuzzy homolog

fuzzy homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05161	FUZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fuz	NCBI	NCBI:80199

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