Fuz - fuzzy planar cell polarity protein Gene

Also Known as b2b1273Clo; 2600013E07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70300

Summary

Involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and positive regulation of protein processing. Predicted to be located in cell projection; cytoplasm; and Cytoskeleton. Is expressed in several structures, including central nervous system; neural ectoderm; and notochord. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]

Fuz Products (9)

mRNA Protein Name
NM_001403450.1 NP_001390379.1 protein fuzzy homolog isoform 1
NM_001403451.1 NP_001390380.1 protein fuzzy homolog isoform 3
NM_001403452.1 NP_001390381.1 protein fuzzy homolog isoform 4
NM_001403453.1 NP_001390382.1 protein fuzzy homolog isoform 5
NM_001403454.1 NP_001390383.1 protein fuzzy homolog isoform 6
NM_001403455.1 NP_001390384.1 protein fuzzy homolog isoform 7
NM_001403456.1 NP_001390385.1 protein fuzzy homolog isoform 8
NM_001403457.1 NP_001390386.1 protein fuzzy homolog isoform 9
NM_027376.4 NP_081652.2 protein fuzzy homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
35427153 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
27158779 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
19877275 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
19877275 MGI
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
19767740 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in embryonic body morphogenesis IMP
IMP: Inferred from mutant phenotype
19767740 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
19877275 MGI
acts upstream of or within embryonic neurocranium morphogenesis IGI
IGI: Inferred from genetic interaction
27395007 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
27395007 MGI
involved in embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
19767740 MGI
involved in establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
19767740 MGI
involved in hair follicle development IMP
IMP: Inferred from mutant phenotype
20962855 MGI
acts upstream of or within larynx morphogenesis IGI
IGI: Inferred from genetic interaction
28177282 MGI
acts upstream of or within larynx morphogenesis IMP
IMP: Inferred from mutant phenotype
28177282 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21935430 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21935430 MGI
involved in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation IMP
IMP: Inferred from mutant phenotype
23806618 MGI
involved in negative regulation of neural crest formation IMP
IMP: Inferred from mutant phenotype
23806618 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
19877275 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
19767740 MGI
involved in non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21935430 MGI
involved in positive regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
21935430 MGI
acts upstream of or within positive regulation of protein processing IMP
IMP: Inferred from mutant phenotype
19877275 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19877275 MGI
involved in regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19767740 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
27158779 MGI
acts upstream of or within spinal cord development IMP
IMP: Inferred from mutant phenotype
19877275 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IMP
IMP: Inferred from mutant phenotype
21761479 MGI
acts upstream of or within tongue morphogenesis IMP
IMP: Inferred from mutant phenotype
27158779 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein fuzzy homolog

  • fuzzy homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05161 FUZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fuz NCBI NCBI:80199