TFPI - tissue factor pathway inhibitor Gene

Also Known as EPI; TFI; LACI; TFPI1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7035

About TFPI

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:187,464,230-187,554,435 (from NCBI)

This gene has 12 transcripts (splice variants), 167 orthologues and 13 paralogues. Broad expression in liver (RPKM 42.6), placenta (RPKM 39.9) and 20 other tissues.

Summary

This gene encodes a Kunitz-type Serine Protease Inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

TFPI Products (6)

mRNA	Protein	Name
NM_001032281.4	NP_001027452.1	tissue factor pathway inhibitor isoform b precursor
NM_001318941.3	NP_001305870.1	tissue factor pathway inhibitor isoform b precursor
NM_001329239.2	NP_001316168.1	tissue factor pathway inhibitor isoform a precursor
NM_001329240.2	NP_001316169.1	tissue factor pathway inhibitor isoform a precursor
NM_001329241.2	NP_001316170.1	tissue factor pathway inhibitor isoform a precursor
NM_006287.6	NP_006278.1	tissue factor pathway inhibitor isoform a precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to steroid hormone stimulus	IEP IEP: Inferred from expression pattern	21868574	GOA
involved in negative regulation of blood coagulation	IDA IDA: Inferred from direct assay	21868574	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	21868574	GOA
located in cell surface	IDA IDA: Inferred from direct assay	21868574	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19065458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFPI Protein Structure

Kunitz_BPTI

0
100
200
304 a.a.

Protein Preferred Names	Protein Names
tissue factor pathway inhibitor	anti-convertin

Recombinant TFPI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77227	TFPI Protein, Human (HEK293, His)	P10646/NP_006278.1(D29-K282)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77228	TFPI Protein, Human (Biotinylated, HEK293, His)	P10646 (D29-K282)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78212	TFPI Protein, Human (Biotinylated, HEK293, His-Avi)	P10646 (D29-K282)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78522	TFPI Protein, Human (HEK293, His-Avi)	P10646 (D29-K282)	≥ 95%, as determined by Bis-Tris PAGE.

TFPI Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83527	Tissue Factor Pathway Inhibitor Antibody (YA3272)	WB, IP	Human
HY-P83527A	Tissue Factor Pathway Inhibitor Antibody (YA3272)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Thrombosis	Thrombosis Of Blood Vessel
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Thrombophilia	Hypercoagulability State
Antiphospholipid Syndrome	Antiphospholipid Antibody Syndrome Hughes Syndrome Familial Antiphospholipid Syndrome Aps Lupus Anticoagulant, Familial Anti-Phospholipid Syndrome Apls Classic Apls Classic Antiphospholipid Syndrome Acromegaloid Facial Appearance Syndrome Anticardiolipin Syndrome
Carotid Stenosis	Carotid Artery Stenosis Stenosis, Carotid Artery
Puerperal Pulmonary Embolism	Obstetric Pulmonary Embolism
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Purpura Fulminans	Purpura Gangrenosa
Factor Viii Deficiency	Autosomal Hemophilia A Hemophilia A Autosomal Factor Viii Deficiency Classic Hemophilia A Congenital Factor Viii Disorder Subhemophilia Factor 8 Deficiency, Congenital Factor Viii
Hemarthrosis	Haemarthrosis Of Shoulder Joint Haemarthrosis Of The Ankle And Foot Haemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Involving Ankle And Foot Hemarthrosis Involving Forearm Hemarthrosis Involving Hand Hemarthrosis Involving Lower Leg Hemarthrosis Involving Pelvic Region And Thigh Hemarthrosis Involving Shoulder Region Hemarthrosis Involving Upper Arm Hemarthrosis Of Ankle And/Or Foot Hemarthrosis Of Forearm Hemarthrosis Of Hand Hemarthrosis Of Lower Leg Hemarthrosis Of Shoulder Hemarthrosis Of Shoulder Region Hemarthrosis Of The Ankle And Foot Hemarthrosis Of The Ankle And/Or Foot Hemarthrosis Of The Forearm Hemarthrosis Of The Hand Hemarthrosis Of The Lower Leg Hemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Of The Shoulder Region Hemarthrosis Of The Upper Arm Hemarthrosis Of Upper Arm
Post-Thrombotic Syndrome	Postphlebitic Syndrome Postthrombotic Syndrome Postphlebetic Syndrome With Inflammation Postphlebetic Syndrome With Ulcer Postphlebetic Syndrome With Ulcer And Inflammation Venous Stress Disorder
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Pulmonary Artery Disease	Abnormality Of The Pulmonary Artery
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Alpha-2-Plasmin Inhibitor Deficiency	Plasmin Inhibitor Deficiency Antiplasmin Deficiency Antiplasmin Defiency Anti-Plasmin Deficiency, Congenital Antiplasmin Deficiency, Congenital Congenital Alpha2-Antiplasmin Deficiency APLID Congenital Alpha2 Antiplasmin Deficiency
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99283	Concizumab		98.12%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153480A	ARC19499 sodium	Inhibitor	99.40%	Phase 1
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99725	Marstacimab		96.27%	Phase 3
HY-P99465	Befovacimab	Inhibitor	97.31%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14427	TFPI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14428	TFPI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17298	Tfpi Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18411	Tfpi2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23753	Tfpi Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24892	Tfpi2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991379	MG1113A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TFPI	RGD	RGD:61914
Mus musculus	TFPI	MGD	MGI:1095418
Macaca mulatta	TFPI	VGNC	VGNC:78328
Felis catus	TFPI	VGNC	VGNC:80378
Bos taurus	TFPI	VGNC	VGNC:106975
Canis familiaris	TFPI	VGNC	VGNC:47301
Others	TFPI	NCBI