1. Gene
  2. TFPI - tissue factor pathway inhibitor Gene

TFPI - tissue factor pathway inhibitor Gene

Homo sapiens

Also known as EPI; TFI; LACI; TFPI1

Gene ID: 7035 | Gene type: protein coding

About TFPI

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:187,464,230-187,554,435 (from NCBI)

This gene has 12 transcripts (splice variants), 167 orthologues and 13 paralogues. Broad expression in liver (RPKM 42.6), placenta (RPKM 39.9) and 20 other tissues.

Summary

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

TFPI Products(6)

mRNA Protein Name
NM_001032281.4 NP_001027452.1 tissue factor pathway inhibitor isoform b precursor
NM_001318941.3 NP_001305870.1 tissue factor pathway inhibitor isoform b precursor
NM_001329239.2 NP_001316168.1 tissue factor pathway inhibitor isoform a precursor
NM_001329240.2 NP_001316169.1 tissue factor pathway inhibitor isoform a precursor
NM_001329241.2 NP_001316170.1 tissue factor pathway inhibitor isoform a precursor
NM_006287.6 NP_006278.1 tissue factor pathway inhibitor isoform a precursor

TFPI Protein Structure

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (53 - 104)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (124 - 175)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (217 - 268)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

tissue factor pathway inhibitor

anti-convertin

Recombinant TFPI Proteins

Cat. No. Product Name Accession Purity
HY-P77227 TFPI Protein, Human (HEK293, His) P10646/NP_006278.1(D29-K282) ≥95%
HY-P77228 TFPI Protein, Human (Biotinylated, HEK293, His) P10646 (D29-K282) ≥95%
HY-P78212 TFPI Protein, Human (Biotinylated, HEK293, His-Avi) P10646 (D29-K282) ≥95%
HY-P78522 TFPI Protein, Human (HEK293, His-Avi) P10646 (D29-K282) ≥95%
HY-P78803 TFPI Protein, Human (Biotinylated, 254a.a, HEK293, His) NP_006278 (D29-K282) ≥95%

Related Diseases

Diseases Alias
Thrombosis

Thrombosis Of Blood Vessel

Disseminated Intravascular Coagulation

Defibrination Syndrome

Dic

Diffuse Or Disseminated Intravascular Coagulation

Fibrinolytic Purpura

Consumption Coagulopathy

Diffuse Intravascular Coagulation

Dic - [Disseminated Intravascular Coagulation]

Disseminated Intravascular Coagulopathy

Fibrinolysis Nos

Thrombolytic Purpura

Thrombophilia

Hypercoagulability State

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome

Hughes Syndrome

Familial Antiphospholipid Syndrome

Aps

Lupus Anticoagulant, Familial

Anti-Phospholipid Syndrome

Apls

Classic Apls

Classic Antiphospholipid Syndrome

Acromegaloid Facial Appearance Syndrome

Anticardiolipin Syndrome

Carotid Stenosis

Carotid Artery Stenosis

Stenosis, Carotid Artery

Puerperal Pulmonary Embolism

Obstetric Pulmonary Embolism

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Purpura Fulminans

Purpura Gangrenosa

Factor Viii Deficiency

Autosomal Hemophilia A

Hemophilia A

Autosomal Factor Viii Deficiency

Classic Hemophilia A

Congenital Factor Viii Disorder

Subhemophilia

Factor 8 Deficiency, Congenital

Factor Viii

Hemarthrosis

Haemarthrosis Of Shoulder Joint

Haemarthrosis Of The Ankle And Foot

Haemarthrosis Of The Pelvic Region And Thigh

Hemarthrosis Involving Ankle And Foot

Hemarthrosis Involving Forearm

Hemarthrosis Involving Hand

Hemarthrosis Involving Lower Leg

Hemarthrosis Involving Pelvic Region And Thigh

Hemarthrosis Involving Shoulder Region

Hemarthrosis Involving Upper Arm

Hemarthrosis Of Ankle And/Or Foot

Hemarthrosis Of Forearm

Hemarthrosis Of Hand

Hemarthrosis Of Lower Leg

Hemarthrosis Of Shoulder

Hemarthrosis Of Shoulder Region

Hemarthrosis Of The Ankle And Foot

Hemarthrosis Of The Ankle And/Or Foot

Hemarthrosis Of The Forearm

Hemarthrosis Of The Hand

Hemarthrosis Of The Lower Leg

Hemarthrosis Of The Pelvic Region And Thigh

Hemarthrosis Of The Shoulder Region

Hemarthrosis Of The Upper Arm

Hemarthrosis Of Upper Arm

Post-Thrombotic Syndrome

Postphlebitic Syndrome

Postthrombotic Syndrome

Postphlebetic Syndrome With Inflammation

Postphlebetic Syndrome With Ulcer

Postphlebetic Syndrome With Ulcer And Inflammation

Venous Stress Disorder

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency

Rosenthal Syndrome

Pta Deficiency

Hemophilia C

Rosenthal Factor Deficiency

F11 Deficiency

Congenital Factor Xi Deficiency

Hereditary Factor Xi Deficiency Disease

Haemophilia C

Factor Xi Deficiency, Autosomal Dominant

Rosenthal'S Disease

Factor 11 Deficiency

Factor Xi

Factor Xi Deficiency, Autosomal Recessive

Factor Xi Deficiency, Congenital

FA11D

Thromboplastin Antecedent Deficiency

Pta - [Plasma Thromboplastin Antecedent] Deficiency

Congenital Factor Xi Deficiency Disease

Rosenthal Disease

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Hemophilia B

Christmas Disease

Factor Ix Deficiency

F9 Deficiency

HEMB

Plasma Thromboplastin Component Deficiency

Congenital Factor Ix Deficiency

Mild Hemophilia B

Severe Hemophilia B

Congenital Factor Ix Disorder

Deficiency, Functional Factor Ix

Hem B

Mild Congenital F9 Deficiency

Mild Congenital Factor Ix Deficiency

Moderate Hemophilia B

Moderate Congenital F9 Deficiency

Moderate Congenital Factor Ix Deficiency

Severe Congenital F9 Deficiency

Severe Congenital Factor Ix Deficiency

Bleeding Disorder In Hemophilia B Carriers

Congenital F9 Deficiency

Recessive X-Linked Hemophilia B

Blood Coagulation Disease

Blood Coagulation Disorders

Coagulation Protein Disease

Inherited Blood Coagulation Disease

Postpartum Coagulation Defect

Postpartum Coagulation Defect With Delivery

Coagulation Protein Disorders

Puerperal Coagulopathy

Alpha-2-Plasmin Inhibitor Deficiency

Plasmin Inhibitor Deficiency

Antiplasmin Deficiency

Antiplasmin Defiency

Anti-Plasmin Deficiency, Congenital

Antiplasmin Deficiency, Congenital

Congenital Alpha2-Antiplasmin Deficiency

APLID

Congenital Alpha2 Antiplasmin Deficiency

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TFPI RGD RGD:61914
Mus musculus TFPI MGD MGI:1095418
Macaca mulatta TFPI VGNC VGNC:78328
Felis catus TFPI VGNC VGNC:80378
Bos taurus TFPI VGNC VGNC:106975
Canis familiaris TFPI VGNC VGNC:47301
Leporidae TFPI NCBI
Others TFPI NCBI