Marstacimab (Synonyms: PF-06741086)

Cat. No.: HY-P99725: FAQs
Data Sheet

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Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia.

For research use only. We do not sell to patients.

Marstacimab Chemical Structure

CAS No. : 1985638-39-8

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Description

Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia^[1]^[2].

In Vitro

Marstacimab (20, 50 and 100 nmol/L) decreases rotational thromboelastometry (ROTEM) corn trypsin (CT) of the whole blood that obtained from haemophilia participants^[1].
Marstacimab (16 μg/mL) decreases the lag time and increases thrombin generation of human nonhemophilic plateletpoor plasma samples in vitro^[2].
Marstacimab (16 μg/mL) increases the peak thrombin in both hemophilia A and hemophilia B plasma samples in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Marstacimab (0.5 mg/kg; i.v., once) does not affect the blood flow situation in mouse acute bleeding models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Acute bleeding hemophilia A mouse models^[2]
Dosage:	0.5 mg/kg
Administration:	Intravenous injection, 0.5 mg/kg, once, before tail clip
Result:	Showed no effect on the blood loss compared with control mice, but significantly reduced the blood loss with the combination of aPCC 200 U/kg.

Clinical Trial

CAS No.

1985638-39-8

SMILES

[Marstacimab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patel-Hett S, et al. Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas. Haemophilia. 2019 Sep;25(5):797-806. [Content Brief]

[2]. Pittman DD, et al. Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model. Res Pract Thromb Haemost. 2022 Mar 16;6(2):e12679. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Marstacimab1985638-39-8PF-06741086PF06741086PF 06741086Otherscorn trypsinROTEMwhole bloodplasmamiceInhibitorinhibitorinhibit

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