Tbce - tubulin-specific chaperone E Gene

Also Known as pmn; 2610206D02Rik; C530005D02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70430

Summary

This gene encodes a tubulin binding cofactor that participates in microtubule dynamics. A mouse model of progressive motor neuropathy (pmn) was discovered to harbor a single amino acid deletion in this gene. Mice that are homozygous for pmn allele exhibit progressive atrophy and premature death due to respiratory failure. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Tbce Products (1)

mRNA Protein Name
NM_178337.3 NP_848027.1 tubulin-specific chaperone E

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
7472523 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
12446740 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
7472523 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
12389029 MGI
acts upstream of or within muscle atrophy IMP
IMP: Inferred from mutant phenotype
7472523 MGI
acts upstream of or within peripheral nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
7472523 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
7472523 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin-specific chaperone E

  • progressive motor neuropathy

  • tubulin-folding cofactor E

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14254 TBCE Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbce NCBI NCBI:6905