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71954

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24

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

2

Recombinant Proteins

10

Antibodies

12

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13543
    Tretazicar

    CB 1954

    		 Quinone Reductase DNA Alkylator/Crosslinker Cancer
    Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .
    Tretazicar
  • HY-18700
    BRD73954
    4 Publications Verification

    		 HDAC Cancer
    BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 µM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin .
    BRD73954
  • HY-18766
    EW-7195
    1 Publications Verification

    		 TGF-β Receptor p38 MAPK Cancer
    EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung .
    EW-7195
  • HY-P991252
    XmAb-7195

    AIMab-7195

    		 Histamine Receptor Inflammation/Immunology
    XmAb-7195 (AIMab-7195) is a human monoclonal antibody (mAb) targeting IGHE. XmAb-7195 can be used in Food hypersensitivity, Allergic asthma, Allergic rhinitis, Atopic dermatitis and Conjunctivitis research .
    XmAb-7195
  • HY-151217
    Ipronidazole

    RO-71554

    		 Parasite Infection
    Ipronidazole (RO-71554) is an orally active antihistomonal agent, which prevents and ameliorates enterohepatitis in turkeys. Ipronidazole can promotes turkey growth when supplied in feed or drinking water .
    Ipronidazole
  • HY-160254
    1954U89

    		Dihydrofolate reductase (DHFR) Cancer
    1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity .
    1954U89
  • HY-151217R
    Ipronidazole (Standard)

    RO-71554 (Standard)

    		 Reference Standards Parasite Infection
    Ipronidazole (Standard) is the analytical standard of Ipronidazole. This product is intended for research and analytical applications. Ipronidazole (RO-71554) is an orally active antihistomonal agent, which prevents and ameliorates enterohepatitis in turkeys. Ipronidazole can promotes turkey growth when supplied in feed or drinking water .
    Ipronidazole (Standard)
  • HY-P5568
    Siamycin III

    RP 71955

    		 HIV Infection
    RP 71955 is an antimicrobial peptide against HIV-1 .
    Siamycin III
  • HY-13543R
    Tretazicar (Standard)

    CB 1954 (Standard)

    		 DNA Alkylator/Crosslinker Reference Standards Cancer
    Tretazicar (Standard) is the analytical standard of Tretazicar. This product is intended for research and analytical applications. Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .
    Tretazicar (Standard)
  • HY-10658
    AC-7954

    		Urotensin Receptor Cardiovascular Disease
    AC-7954 is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor) .
    AC-7954
  • HY-19161
    Bay-X-7195

    		Leukotriene Receptor Inflammation/Immunology
    Bay-X-7195 is a CYS leukotriene 1 receptor (CYS LT1) antagonist. Bay-X-7195 shows an antagonistic action to LTD4-induced bronchoconstriction in vitro and in vivo. Bay-X-7195 can be used foe the study of allergic and asthmatic .
    Bay-X-7195
  • HY-RI02773A
    mmu-miR-1954 antagomir

    		MicroRNA Cancer
    mmu-miR-1954 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-1954 antagomir
    mmu-miR-1954 antagomir
  • HY-R02773
    mmu-miR-1954 mimic

    		MicroRNA Cancer
    mmu-miR-1954 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1954 mimic
    mmu-miR-1954 mimic
  • HY-129648
    AC-7954 free base

    		Urotensin Receptor Cardiovascular Disease
    AC-7954 free base is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor) .
    AC-7954 free base
  • HY-R02381
    hsa-miR-7154-3p mimic

    		MicroRNA Cancer
    hsa-miR-7154-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-7154-3p mimic
    hsa-miR-7154-3p mimic
  • HY-R02382A
    hsa-miR-7154-5p agomir

    		MicroRNA Cancer
    hsa-miR-7154-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-7154-5p agomir
    hsa-miR-7154-5p agomir
  • HY-R02382
    hsa-miR-7154-5p mimic

    		MicroRNA Cancer
    hsa-miR-7154-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-7154-5p mimic
    hsa-miR-7154-5p mimic
  • HY-RI02773
    mmu-miR-1954 inhibitor

    		MicroRNA Cancer
    mmu-miR-1954 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1954 inhibitor
    mmu-miR-1954 inhibitor
  • HY-R02773A
    mmu-miR-1954 agomir

    		MicroRNA Cancer
    mmu-miR-1954 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-1954 agomir
    mmu-miR-1954 agomir
  • HY-RI02381A
    hsa-miR-7154-3p antagomir

    		MicroRNA Cancer
    hsa-miR-7154-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-7154-3p antagomir
    hsa-miR-7154-3p antagomir
  • HY-RI02381
    hsa-miR-7154-3p inhibitor

    		MicroRNA Cancer
    hsa-miR-7154-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-7154-3p inhibitor
    hsa-miR-7154-3p inhibitor
  • HY-R02381A
    hsa-miR-7154-3p agomir

    		MicroRNA Cancer
    hsa-miR-7154-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-7154-3p agomir
    hsa-miR-7154-3p agomir
  • HY-RI02382A
    hsa-miR-7154-5p antagomir

    		MicroRNA Cancer
    hsa-miR-7154-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-7154-5p antagomir
    hsa-miR-7154-5p antagomir
  • HY-RI02382
    hsa-miR-7154-5p inhibitor

    		MicroRNA Cancer
    hsa-miR-7154-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-7154-5p inhibitor
    hsa-miR-7154-5p inhibitor

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