TTLL7 - tubulin tyrosine ligase like 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79739

About TTLL7

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:83,865,024-83,999,132 (from NCBI)

This gene has 14 transcripts (splice variants), 195 orthologues and 12 paralogues. Broad expression in brain (RPKM 22.0), prostate (RPKM 4.2) and 14 other tissues.

Summary

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and tubulin-glutamic acid Ligase activity. Involved in protein polyglutamylation. Predicted to be located in 9+0 non-motile cilium and ciliary basal body. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Apr 2022]

TTLL7 Products (3)

mRNA Protein Name
NM_001350214.2 NP_001337143.1 tubulin polyglutamylase TTLL7 isoform 1
NM_001350215.2 NP_001337144.1 tubulin polyglutamylase TTLL7 isoform 2
NM_024686.6 NP_078962.4 tubulin polyglutamylase TTLL7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
25959773 GOA
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
25959773 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables tubulin-glutamic acid ligase activity IDA
IDA: Inferred from direct assay
25959773 GOA
Biological Process GO Annotation Evidence References Source
involved in protein polyglutamylation IDA
IDA: Inferred from direct assay
25959773 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTLL7 Protein Structure

TTL

TTL: Tubulin-tyrosine ligase family (90 - 379)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

tubulin polyglutamylase TTLL7

  • testis development protein NYD-SP30

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15234 TTLL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TTLL7 VGNC VGNC:36495
Felis catus TTLL7 VGNC VGNC:66689
Canis familiaris TTLL7 VGNC VGNC:47978
Macaca mulatta TTLL7 VGNC VGNC:79591
Mus musculus TTLL7 MGD MGI:1918142
Rattus norvegicus TTLL7 RGD RGD:1566117
Others TTLL7 NCBI