TMC5 - transmembrane channel like 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79838

About TMC5

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:19,410,539-19,499,113 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 21.9), stomach (RPKM 18.3) and 10 other tissues.

Summary

Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

TMC5 Products (5)

mRNA Protein Name
NM_001105248.1 NP_001098718.1 transmembrane channel-like protein 5 isoform a
NM_001105249.1 NP_001098719.1 transmembrane channel-like protein 5 isoform b
NM_001261841.2 NP_001248770.1 transmembrane channel-like protein 5 isoform a
NM_001308161.1 NP_001295090.1 transmembrane channel-like protein 5 isoform d
NM_024780.5 NP_079056.2 transmembrane channel-like protein 5 isoform c

TMC5 Protein Structure

TMC

TMC: TMC domain (724 - 830)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1006 a.a.
Protein Preferred Names Protein Names

transmembrane channel-like protein 5

Related Diseases

Diseases Alias
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14625 TMC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMC5 VGNC VGNC:66236
Mus musculus TMC5 MGD MGI:1921674
Canis familiaris TMC5 VGNC VGNC:47424
Macaca mulatta TMC5 VGNC VGNC:79366
Bos taurus TMC5 VGNC VGNC:35921
Rattus norvegicus TMC5 RGD RGD:1307037
Others TMC5 NCBI