TMC5 - transmembrane channel like 5 Gene

Homo sapiens

Gene ID: 79838 | Gene type: protein coding

About TMC5

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:19,410,539-19,499,113 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 21.9), stomach (RPKM 18.3) and 10 other tissues.

Summary

Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

TMC5 Products(5)

mRNA	Protein	Name
NM_001105248.1	NP_001098718.1	transmembrane channel-like protein 5 isoform a
NM_001105249.1	NP_001098719.1	transmembrane channel-like protein 5 isoform b
NM_001261841.2	NP_001248770.1	transmembrane channel-like protein 5 isoform a
NM_001308161.1	NP_001295090.1	transmembrane channel-like protein 5 isoform d
NM_024780.5	NP_079056.2	transmembrane channel-like protein 5 isoform c

TMC5 Protein Structure

TMC

0
200
400
600
800
1006 a.a.

Protein Preferred Names

Protein Names

transmembrane channel-like protein 5

Related Diseases

Diseases

Alias

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14625	TMC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMC5	VGNC	VGNC:66236
Mus musculus	TMC5	MGD	MGI:1921674
Canis familiaris	TMC5	VGNC	VGNC:47424
Macaca mulatta	TMC5	VGNC	VGNC:79366
Bos taurus	TMC5	VGNC	VGNC:35921
Rattus norvegicus	TMC5	RGD	RGD:1307037

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