2. Gene
  3. FBXL18 - F-box and leucine rich repeat protein 18 Gene

FBXL18 - F-box and leucine rich repeat protein 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Fbl18

Gene ID: 80028 | Gene type: protein coding

About FBXL18

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,454,425-5,513,809 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 15 paralogues. Ubiquitous expression in brain (RPKM 2.3), fat (RPKM 1.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]

FBXL18 Products(6)

mRNA Protein Name
NM_001321213.2 NP_001308142.1 F-box/LRR-repeat protein 18 isoform 1
NM_001363441.2 NP_001350370.1 F-box/LRR-repeat protein 18 isoform 3
NM_001363442.2 NP_001350371.1 F-box/LRR-repeat protein 18 isoform 4
NM_001367780.1 NP_001354709.1 F-box/LRR-repeat protein 18 isoform 5
NM_001367781.1 NP_001354710.1 F-box/LRR-repeat protein 18 isoform 5
NM_024963.6 NP_079239.3 F-box/LRR-repeat protein 18 isoform 2

FBXL18 Protein Structure

F-box-like

F-box-like: F-box-like (33 - 74)

  • 0
  • 200
  • 400
  • 600
  • 718 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 18

Related Diseases

Diseases Alias
Baraitser-Winter Syndrome

Fryns-Aftimos Syndrome

Brws

Cerebro-Frontofacial Syndrome, Type 3

Iris Coloboma With Ptosis, Hypertelorism, And Mental Retardation

Iris Coloboma With Ptosis Hypertelorism And Intellectual Disability

Trigonocephaly Ptosis Coloboma

Trigonocephaly Ptosis Intellectual Disability

Cerebrofrontofacial Syndrome Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04787 FBXL18 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FBXL18 VGNC VGNC:62174
Macaca mulatta FBXL18 VGNC VGNC:72549
Canis familiaris FBXL18 VGNC VGNC:54024
Bos taurus FBXL18 VGNC VGNC:52774
Rattus norvegicus FBXL18 RGD RGD:1596958
Mus musculus FBXL18 MGD MGI:2444450