ADAMTS20 - ADAM metallopeptidase with thrombospondin type 1 motif 20 Gene

Also Known as GON-1; ADAM-TS20; ADAMTS-20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80070

About ADAMTS20

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:43,352,763-43,552,203 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]

ADAMTS20 Products (1)

mRNA Protein Name
NM_025003.5 NP_079279.3 A disintegrin and metalloproteinase with thrombospondin motifs 20 preproprotein

ADAMTS20 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (40 - 186)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (259 - 467)

TSP_1

TSP_1: Thrombospondin type 1 domain (560 - 610)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (721 - 840)

TSP_1

TSP_1: Thrombospondin type 1 domain (972 - 1000)

TSP_1

TSP_1: Thrombospondin type 1 domain (1028 - 1077)

TSP_1

TSP_1: Thrombospondin type 1 domain (1082 - 1134)

TSP_1

TSP_1: Thrombospondin type 1 domain (1159 - 1180)

TSP_1

TSP_1: Thrombospondin type 1 domain (1214 - 1262)

TSP_1

TSP_1: Thrombospondin type 1 domain (1310 - 1356)

TSP_1

TSP_1: Thrombospondin type 1 domain (1365 - 1415)

TSP_1

TSP_1: Thrombospondin type 1 domain (1424 - 1474)

TSP_1

TSP_1: Thrombospondin type 1 domain (1481 - 1525)

TSP_1

TSP_1: Thrombospondin type 1 domain (1661 - 1684)

GON

GON: GON domain (1713 - 1909)

  • 0
  • 300
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  • 1200
  • 1500
  • 1800
  • 1910 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 20

  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20

Related Diseases

Diseases Alias
Peters-Plus Syndrome

  • Krause-Kivlin Syndrome

  • Peters Plus Syndrome

  • Peters Anomaly

  • Irido-Corneo-Trabecular Dysgenesis

  • PTRPLS

  • Peters Anomaly With Short-Limb Dwarfism

  • Peters Anomaly-Short Limb Dwarfism Syndrome

  • Peters Anomaly With Short Limb Dwarfism

  • Peters Congenital Glaucoma

  • Krause-Van Schooneveld-Kivlin Syndrome

  • Peters' Plus Syndrome

  • Peters'-Plus Syndrome

  • Anomaly Peters
Cervical Large Cell Neuroendocrine Carcinoma
Otospondylomegaepiphyseal Dysplasia, Autosomal Recessive

  • Osmed

  • Otospondylomegaepiphyseal Dysplasia

  • Chondrodystrophy With Sensorineural Deafness

  • Nance-Insley Syndrome

  • Nance-Sweeney Chondrodysplasia

  • OSMEDB

  • Insley-Astley Syndrome

  • Osmed Syndrome

  • Mega-Epiphyseal Dwarfism

  • Weissenbacher-Zweymuller Syndrome, Formerly

  • Wzs, Formerly

  • Nance Sweeney Chondrodysplasia

  • Oto-Spondylo-Mega-Epiphyseal Dysplasia

  • Oto-Spondylo-Megaepiphyseal Dysplasia

  • Megaepiphyseal Dwarfism
Ehlers-Danlos Syndrome, Dermatosparaxis Type

  • Dermatosparaxis

  • EDSDERMS

  • Ehlers-Danlos Syndrome, Type Vii, Autosomal Recessive

  • Eds Viic

  • Eds7c

  • Ehlers-Danlos Syndrome Dermatosparaxis Type

  • Dermatosparaxis Ehlers-Danlos Syndrome

  • Dermatosparaxis Eds

  • Ehlers-Danlos Syndrome Type 7c

  • Deds

  • Human Dermatosparaxis Eds Viic

  • Ehlers-Danlos Syndrome 7c

  • Ehlers-Danlos Syndrome, Type Viic
Weill-Marchesani Syndrome

  • Gemss Syndrome

  • Spherophakia-Brachymorphia Syndrome

  • Marchesani-Weill Syndrome

  • Wms

  • Congenital Mesodermal Dystrophy

  • Mesodermal Dysmorphodystrophy, Congenital

  • Spherophakia Brachymorphia Syndrome

  • Mesodermal Dysmorphodystrophy Congenital

  • Wm Syndrome

  • Brachydactyly-Spherophakia Syndrome

  • Brachymorphy With Spherophakia Syndrome

  • Congenital Mesodermal Dysmorphodystrophy

  • Marchesani Syndrome

  • Weill-Marchesani Syndrome, Autosomal Recessive

  • Weill-Marchesani Syndrome, Autosomal Dominant
Geleophysic Dysplasia

  • Geleophysic Dwarfism

  • Gphysd
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Chromosome 2q35 Duplication Syndrome

  • Syndactyly

  • Syndactyly Type 1

  • Sdty1

  • Zygodactyly

  • Syndactyly, Type I

  • Sd1

  • Syndactyly, Type 1, With Or Without Craniosynostosis

  • Symphalangism

  • Non-Syndromic Syndactyly

  • Symphalangy

  • Webbing Of Digits

  • Syndactyly, Type 1
Orofacial Cleft

  • Cleft, Orofacial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00302 ADAMTS20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19289 Adamts20 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25779 Adamts20 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADAMTS20 VGNC VGNC:37599
Rattus norvegicus ADAMTS20 RGD RGD:1307725
Mus musculus ADAMTS20 MGD MGI:2660628
Bos taurus ADAMTS20 VGNC VGNC:25625
Macaca mulatta ADAMTS20 VGNC VGNC:69444
Felis catus ADAMTS20 VGNC VGNC:59593
Others ADAMTS20 NCBI