ADAMTS20 - ADAM metallopeptidase with thrombospondin type 1 motif 20 Gene

Homo sapiens

Also known as GON-1; ADAM-TS20; ADAMTS-20

Gene ID: 80070 | Gene type: protein coding

About ADAMTS20

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:43,352,763-43,552,203 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]

ADAMTS20 Products(1)

mRNA	Protein	Name
NM_025003.5	NP_079279.3	A disintegrin and metalloproteinase with thrombospondin motifs 20 preproprotein

ADAMTS20 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

GON

0
300
600
900
1200
1500
1800
1910 a.a.

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 20

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20

Related Diseases

Diseases

Alias

Peters-Plus Syndrome

Krause-Kivlin Syndrome	Peters Plus Syndrome
Peters Anomaly	Irido-Corneo-Trabecular Dysgenesis
PTRPLS	Peters Anomaly With Short-Limb Dwarfism
Peters Anomaly-Short Limb Dwarfism Syndrome	Peters Anomaly With Short Limb Dwarfism
Peters Congenital Glaucoma	Krause-Van Schooneveld-Kivlin Syndrome
Peters' Plus Syndrome	Peters'-Plus Syndrome
Anomaly Peters

Cervical Large Cell Neuroendocrine Carcinoma

Otospondylomegaepiphyseal Dysplasia, Autosomal Recessive

Osmed	Otospondylomegaepiphyseal Dysplasia
Chondrodystrophy With Sensorineural Deafness	Nance-Insley Syndrome
Nance-Sweeney Chondrodysplasia	OSMEDB
Insley-Astley Syndrome	Osmed Syndrome
Mega-Epiphyseal Dwarfism	Weissenbacher-Zweymuller Syndrome, Formerly
Wzs, Formerly	Nance Sweeney Chondrodysplasia
Oto-Spondylo-Mega-Epiphyseal Dysplasia	Oto-Spondylo-Megaepiphyseal Dysplasia
Megaepiphyseal Dwarfism

Ehlers-Danlos Syndrome, Dermatosparaxis Type

Dermatosparaxis	EDSDERMS
Ehlers-Danlos Syndrome, Type Vii, Autosomal Recessive	Eds Viic
Eds7c	Ehlers-Danlos Syndrome Dermatosparaxis Type
Dermatosparaxis Ehlers-Danlos Syndrome	Dermatosparaxis Eds
Ehlers-Danlos Syndrome Type 7c	Deds
Human Dermatosparaxis Eds Viic	Ehlers-Danlos Syndrome 7c
Ehlers-Danlos Syndrome, Type Viic

Weill-Marchesani Syndrome

Gemss Syndrome	Spherophakia-Brachymorphia Syndrome
Marchesani-Weill Syndrome	Wms
Congenital Mesodermal Dystrophy	Mesodermal Dysmorphodystrophy, Congenital
Spherophakia Brachymorphia Syndrome	Mesodermal Dysmorphodystrophy Congenital
Wm Syndrome	Brachydactyly-Spherophakia Syndrome
Brachymorphy With Spherophakia Syndrome	Congenital Mesodermal Dysmorphodystrophy
Marchesani Syndrome	Weill-Marchesani Syndrome, Autosomal Recessive
Weill-Marchesani Syndrome, Autosomal Dominant

Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

Orofacial Cleft

Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00302	ADAMTS20 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADAMTS20	VGNC	VGNC:37599
Rattus norvegicus	ADAMTS20	RGD	RGD:1307725
Mus musculus	ADAMTS20	MGD	MGI:2660628
Bos taurus	ADAMTS20	VGNC	VGNC:25625
Macaca mulatta	ADAMTS20	VGNC	VGNC:69444
Felis catus	ADAMTS20	VGNC	VGNC:59593
Others	ADAMTS20	NCBI

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