MOGAT2 - monoacylglycerol O-acyltransferase 2 Gene

Also Known as hDC5; MGAT2; DGAT2L5; DGAT2L5.

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80168

About MOGAT2

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,717,838-75,732,953 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 52.4), duodenum (RPKM 48.1) and 2 other tissues.

Summary

The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]

MOGAT2 Products (1)

mRNA Protein Name
NM_025098.4 NP_079374.2 2-acylglycerol O-acyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-acylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
27184406 GOA
Biological Process GO Annotation Evidence References Source
involved in monoacylglycerol biosynthetic process IDA
IDA: Inferred from direct assay
28420705 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14966132 GOA
located in perinuclear endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
27184406 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOGAT2 Protein Structure

DAGAT

DAGAT: Diacylglycerol acyltransferase (41 - 333)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

2-acylglycerol O-acyltransferase 2

  • acyl-CoA:monoacylglycerol acyltransferase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08585 MOGAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MOGAT2 MGD MGI:2663253
Felis catus MOGAT2 VGNC VGNC:63551
Canis familiaris MOGAT2 VGNC VGNC:43309
Macaca mulatta MOGAT2 VGNC VGNC:74806
Rattus norvegicus MOGAT2 RGD RGD:1598060
Others MOGAT2 NCBI