TAS1R1 - taste 1 receptor member 1 Gene

Also Known as TR1; T1R1; GM148; GPR70

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80835

About TAS1R1

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,555,307-6,579,755 (from NCBI)

This gene has 4 transcripts (splice variants), 111 orthologues and 4 paralogues. Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid Taste Receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or Other compounds. Most Amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

TAS1R1 Products (2)

mRNA Protein Name
NM_138697.4 NP_619642.2 taste receptor type 1 member 1 isoform b precursor
NM_177540.3 NP_803884.1 taste receptor type 1 member 1 isoform c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables taste receptor activity IPI
IPI: Inferred from physical interaction
11917125 GOA
Biological Process GO Annotation Evidence References Source
involved in sensory perception of umami taste IDA
IDA: Inferred from direct assay
11917125 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAS1R1 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 456)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (493 - 545)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (577 - 815)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 841 a.a.
Protein Preferred Names Protein Names

taste receptor type 1 member 1

  • G-protein coupled receptor 70

Related Diseases

Diseases Alias
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Glucocorticoid Deficiency 1

  • Acth Resistance

  • Glucocorticoid Deficiency, Due To Acth Unresponsiveness

  • GCCD1

  • Familial Glucocorticoid Deficiency 1

  • Fgd1

  • Adrenal Unresponsiveness To Acth

  • Hereditary Unresponsiveness To Adrenocorticotropic Hormone

  • Isolated Glucocorticoid Deficiency
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 1

  • PKD1

  • Adpkd

  • Polycystic Kidney Disease, Adult, Type I

  • Apkd1

  • Potter Type Iii Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult

  • Potter Type Iii Polycystic Kidney Disease, Formerly

  • Polycystic Kidney Disease, Type 1

  • Adpkd1

  • Adult Polycystic Kidney Disease Type 1

  • Autosomal Dominant Polycystic Kidney Disease 1

  • Pkd-1

  • Polycystic Kidney Disease Adult

  • Polycystic Kidney Disease Type I

  • Polycystic Kidneys

  • Polycystic Kidney Disease, Adult Type I

  • Polycystic Kidney Type 1 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 1

  • Polycystic Kidney, Autosomal Dominant

  • Polycystic Kidney, Type 1 Autosomal Dominant Disease

  • Polycystic Kidney Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14212 TAS1R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TAS1R1 VGNC VGNC:35607
Mus musculus TAS1R1 MGD MGI:1927505
Macaca mulatta TAS1R1 VGNC VGNC:78115
Canis familiaris TAS1R1 VGNC VGNC:47112
Felis catus TAS1R1 VGNC VGNC:65958
Rattus norvegicus TAS1R1 RGD RGD:61891
Others TAS1R1 NCBI