TRIM11 - tripartite motif containing 11 Gene

Also Known as BIA1; RNF92

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81559

About TRIM11

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,393,676-228,406,835 (from NCBI)

This gene has 6 transcripts (splice variants), 96 orthologues and 80 paralogues. Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

TRIM11 Products (1)

mRNA Protein Name
NM_145214.3 NP_660215.1 E3 ubiquitin-protein ligase TRIM11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16904669 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
27498865 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
27498865 GOA
Biological Process GO Annotation Evidence References Source
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
18248090 GOA
involved in negative regulation of AIM2 inflammasome complex assembly IDA
IDA: Inferred from direct assay
27498865 GOA
involved in negative regulation of viral entry into host cell IMP
IMP: Inferred from mutant phenotype
18248090 GOA
involved in negative regulation of viral transcription IDA
IDA: Inferred from direct assay
18248090 GOA
involved in positive regulation of viral entry into host cell IMP
IMP: Inferred from mutant phenotype
18248090 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
27498865 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
27498865 GOA
involved in suppression of viral release by host IDA
IDA: Inferred from direct assay
18248090 GOA
involved in suppression of viral release by host IMP
IMP: Inferred from mutant phenotype
18248090 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18248090 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM11 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (16 - 56)

zf-B_box

zf-B_box: B-box zinc finger (90 - 128)

PRY

PRY: SPRY-associated domain (289 - 337)

SPRY

SPRY: SPRY domain (339 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM11

  • RING finger protein 92

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15020 TRIM11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIM11 VGNC VGNC:79024
Canis familiaris TRIM11 VGNC VGNC:47804
Rattus norvegicus TRIM11 RGD RGD:1305448
Mus musculus TRIM11 MGD MGI:2137355
Felis catus TRIM11 VGNC VGNC:102353
Bos taurus TRIM11 VGNC VGNC:36313
Others TRIM11 NCBI