PCDH11Y - protocadherin 11 Y-linked Gene

Homo sapiens

Also known as PCDHX; PCDHY; PCDH22; PCDH-PC

Gene ID: 83259 | Gene type: protein coding

About PCDH11Y

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:5,000,296-5,742,228 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 33 paralogues. Biased expression in brain (RPKM 1.4), ovary (RPKM 0.6) and 5 other tissues.

Summary

This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical Cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

PCDH11Y Products(5)

mRNA	Protein	Name
NM_001278619.2	NP_001265548.1	protocadherin-11 Y-linked isoform a
NM_001395587.1	NP_001382516.1	protocadherin-11 Y-linked isoform d
NM_032971.3	NP_116753.1	protocadherin-11 Y-linked isoform a
NM_032972.3	NP_116754.1	protocadherin-11 Y-linked isoform b precursor
NM_032973.2	NP_116755.1	protocadherin-11 Y-linked isoform c precursor

PCDH11Y Protein Structure

Cadherin_2

Cadherin

Protocadherin

0
300
600
900
1200
1319 a.a.

Protein Preferred Names

Protein Names

protocadherin-11 Y-linked

protocadherin 22

Related Diseases

Diseases

Alias

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10123	PCDH11Y Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PCDH11Y	MGD	MGI:2442849

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