THOC3 - THO complex subunit 3 Gene

Also Known as THO3; hTREX45

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84321

About THOC3

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,959,531-175,968,315 (from NCBI)

This gene has 12 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 21.2) and 24 other tissues.

Summary

This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]

THOC3 Products (2)

mRNA Protein Name
NM_001376902.1 NP_001363831.1 THO complex subunit 3 isoform 2
NM_032361.4 NP_115737.1 THO complex subunit 3 isoform 1

THOC3 Protein Structure

WD40

WD40: WD domain, G-beta repeat (48 - 81)

WD40

WD40: WD domain, G-beta repeat (95 - 128)

PD40

PD40: WD40-like Beta Propeller Repeat (138 - 157)

WD40

WD40: WD domain, G-beta repeat (215 - 252)

WD40

WD40: WD domain, G-beta repeat (268 - 290)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

THO complex subunit 3

  • TEX1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14493 THOC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris THOC3 VGNC VGNC:47350
Mus musculus THOC3 MGD MGI:1920916
Macaca mulatta THOC3 VGNC VGNC:79176
Rattus norvegicus THOC3 RGD RGD:1311669
Bos taurus THOC3 VGNC VGNC:58351
Others THOC3 NCBI