TPST2 - tyrosylprotein sulfotransferase 2 Gene

Also Known as TPST-2; TANGO13B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8459

About TPST2

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:26,521,996-26,590,132 (from NCBI)

This gene has 9 transcripts (splice variants), 154 orthologues and 1 paralogue. Ubiquitous expression in pancreas (RPKM 24.6), placenta (RPKM 15.2) and 24 other tissues.

Summary

The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]

TPST2 Products (4)

mRNA Protein Name
NM_001008566.3 NP_001008566.1 protein-tyrosine sulfotransferase 2 isoform 1 precursor
NM_001362922.2 NP_001349851.1 protein-tyrosine sulfotransferase 2 isoform 1 precursor
NM_001362923.2 NP_001349852.1 protein-tyrosine sulfotransferase 2 isoform 2
NM_003595.5 NP_003586.3 protein-tyrosine sulfotransferase 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
23481380 GOA
enables protein-tyrosine sulfotransferase activity IDA
IDA: Inferred from direct assay
9733778 GOA
Biological Process GO Annotation Evidence References Source
involved in peptidyl-tyrosine sulfation IDA
IDA: Inferred from direct assay
9733778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPST2 Protein Structure

Sulfotransfer_3

Sulfotransfer_3: Sulfotransferase family (70 - 262)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

protein-tyrosine sulfotransferase 2

  • transport and golgi organization 13 homolog B

Related Diseases

Diseases Alias
Chondrodysplasia With Joint Dislocations, Gpapp Type

  • Gpapp Deficiency

  • Chondrodysplasia With Joint Dislocations Gpapp Type

  • CDP-GPAPP

  • Chondrodysplasia, With Joint Dislocations, Gpapp Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179288 TPST2-IN-1 Inhibitor / Unkown
HY-E70190 Tyrosylprotein Sulfotransferase 2 Activator / Unkown
HY-RS14955 TPST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TPST2 VGNC VGNC:36265
Felis catus TPST2 VGNC VGNC:66488
Rattus norvegicus TPST2 RGD RGD:1305331
Macaca mulatta TPST2 VGNC VGNC:78639
Mus musculus TPST2 MGD MGI:1309516
Canis familiaris TPST2 VGNC VGNC:47756
Others TPST2 NCBI