ATOH8 - atonal bHLH transcription factor 8 Gene

Also Known as HATH6; bHLHa21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84913

About ATOH8

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,753,991-85,791,383 (from NCBI)

This gene has 5 transcripts (splice variants), 175 orthologues and 15 paralogues. Broad expression in fat (RPKM 7.4), lung (RPKM 4.9) and 19 other tissues.

Summary

Enables DNA-binding transcription factor activity and E-box binding activity. Involved in several processes, including SMAD protein signal transduction; positive regulation of endothelial cell differentiation; and regulation of gene expression. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATOH8 Products (1)

mRNA Protein Name
NM_032827.7 NP_116216.2 transcription factor ATOH8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
24236640 GOA
enables E-box binding IDA
IDA: Inferred from direct assay
24236640 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26496921 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
24463812 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27780851 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
24236640 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
24236640 GOA
involved in positive regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
24463812 GOA
involved in positive regulation of endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
24463812 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
24463812 GOA
involved in positive regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
27780851 GOA
involved in tube formation IMP
IMP: Inferred from mutant phenotype
24463812 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24463812 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATOH8 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (231 - 282)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

transcription factor ATOH8

  • atonal homolog 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01167 ATOH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATOH8 VGNC VGNC:79995
Macaca mulatta ATOH8 VGNC VGNC:106131
Rattus norvegicus ATOH8 RGD RGD:1561512
Mus musculus ATOH8 MGD MGI:1918343
Bos taurus ATOH8 VGNC VGNC:26272
Others ATOH8 NCBI