SERPINB12 - serpin family B member 12 Gene

Also Known as YUKOPIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89777

About SERPINB12

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,519,110-63,569,329 (from NCBI)

This gene has 3 transcripts (splice variants), 90 orthologues and 36 paralogues. Restricted expression toward skin (RPKM 27.9).

Summary

Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

SERPINB12 Products (2)

mRNA Protein Name
NM_001307928.2 NP_001294857.1 serpin B12 isoform 1
NM_080474.2 NP_536722.1 serpin B12 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables serine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
11604408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB12 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (7 - 405)

  • 0
  • 100
  • 200
  • 300
  • 405 a.a.
Protein Preferred Names Protein Names

serpin B12

  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12

Recombinant SERPINB12 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71304 Serpin B12 Protein, Human (HEK293, His) Q96P63-2 (M1-P425) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12708 SERPINB12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERPINB12 RGD RGD:1566382
Felis catus SERPINB12 VGNC VGNC:80485
Macaca mulatta SERPINB12 VGNC VGNC:77231
Mus musculus SERPINB12 MGD MGI:1919119
Canis familiaris SERPINB12 VGNC VGNC:46028
Bos taurus SERPINB12 VGNC VGNC:34471
Others SERPINB12 NCBI