KCNH7 - potassium voltage-gated channel subfamily H member 7 Gene

Also Known as ERG3; HERG3; Kv11.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90134

About KCNH7

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,371,407-162,838,767 (from NCBI)

This gene has 4 transcripts (splice variants), 290 orthologues and 17 paralogues. Biased expression in brain (RPKM 1.6), testis (RPKM 0.5) and 3 other tissues.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KCNH7 Products (2)

mRNA Protein Name
NM_033272.4 NP_150375.2 potassium voltage-gated channel subfamily H member 7 isoform 1
NM_173162.3 NP_775185.1 potassium voltage-gated channel subfamily H member 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heme binding IDA
IDA: Inferred from direct assay
32723862 GOA
enables inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
32723862 GOA
Biological Process GO Annotation Evidence References Source
involved in potassium ion transport IDA
IDA: Inferred from direct assay
32723862 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNH7 Protein Structure

PAS_9

PAS_9: PAS domain (31 - 134)

Ion_trans

Ion_trans: Ion transport protein (453 - 662)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (766 - 850)

  • 0
  • 200
  • 400
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  • 800
  • 1000
  • 1196 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 7

  • ERG-3

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 1a

  • DFNB1A

  • Deafness, Digenic, Gjb2/Gjb3

  • Autosomal Recessive Nonsyndromic Deafness 1a

  • Deafness, Digenic, Gjb2/Gjb6

  • Deafness, Digenic Gjb2/Gjb6

  • Autosomal Recessive Deafness 1a

  • Deafness, Autosomal Recessive, 1a

  • Deafness Digenic Gjb2/Gjb3

  • Deafness Digenic Gjb2/Gjb6

  • Deafness Neurosensory Autosomal Recessive 1

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 1

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 1

  • Nsrd1

  • Deafness, Autosomal Recessive, Type 1a
Pseudohypoaldosteronism, Type I, Autosomal Recessive

  • Autosomal Recessive Pseudohypoaldosteronism Type 1

  • PHA1B

  • Pseudohypoaldosteronism Type 1

  • Pseudohypoaldosteronism, Type I

  • Generalized Pha1

  • Generalized Pseudohypoaldosteronism Type 1

  • Pseudohypoaldosteronism Type 1 Autosomal Recessive

  • Pha1

  • Pseudohypoaldosteronism

  • Pha I, Autosomal Recessive

  • Autosomal Recessive Pha 1

  • Pseudohypoaldosteronism Type 1, Recessive

  • Pseudohypoaldosteronism Type I

  • Autosomal Recessive Pha1

  • Pha Type 1

  • Pseudohypoaldosteronism 1, Autosomal Recessive

  • Multisystem Pseudohypoaldosteronism

  • Pha Type I, Autosomal Recessive

  • Pseudohypoaldosteronism Type I, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07130 KCNH7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21610 Kcnh7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28128 Kcnh7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KCNH7 RGD RGD:621112
Bos taurus KCNH7 VGNC VGNC:30449
Macaca mulatta KCNH7 VGNC VGNC:73854
Canis familiaris KCNH7 VGNC VGNC:42252
Mus musculus KCNH7 MGD MGI:2159566
Felis catus KCNH7 VGNC VGNC:63038
Others KCNH7 NCBI