HS6ST2 - heparan sulfate 6-O-sulfotransferase 2 Gene

Also Known as MRXSPM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90161

About HS6ST2

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,626,015-132,961,370 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 4.4), ovary (RPKM 4.1) and 11 other tissues.

Summary

Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HS6ST2 Products (4)

mRNA Protein Name
NM_001077188.2 NP_001070656.1 heparan-sulfate 6-O-sulfotransferase 2 isoform L
NM_001394073.1 NP_001381002.1 heparan-sulfate 6-O-sulfotransferase 2 isoform L
NM_001394074.1 NP_001381003.1 heparan-sulfate 6-O-sulfotransferase 2 isoform S
NM_147175.4 NP_671704.3 heparan-sulfate 6-O-sulfotransferase 2 isoform S

HS6ST2 Protein Structure

Sulfotransfer_2

Sulfotransfer_2: Sulfotransferase family (220 - 491)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
Protein Preferred Names Protein Names

heparan-sulfate 6-O-sulfotransferase 2

  • HS6ST-2

Related Diseases

Diseases Alias
Paganini-Miozzo Syndrome

  • MRXSPM

  • Mental Retardation, X-Linked, Syndromic, Paganini-Miozzo Type
Cartilage Cancer

  • Chondrogenic Neoplasm
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Vulto-Van Silfhout-De Vries Syndrome

  • Vulto-Van Silfout-De Vries Syndrome

  • VSVS

  • Intellectual Developmental Disorder With Impaired Expressive Speech And Behavioral Abnormalities, With Or Without Seizures

  • Iddisbas

  • Mrd24

  • Mental Retardation, Autosomal Dominant 24

  • Autosomal Dominant Mental Retardation 24

  • Autosomal Dominant Non-Syndromic Intellectual Disability 24

  • Mental Retardation, Autosomal Dominant, Type 24
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06383 HS6ST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HS6ST2 VGNC VGNC:41794
Rattus norvegicus HS6ST2 RGD RGD:1564397
Mus musculus HS6ST2 MGD MGI:1354959
Macaca mulatta HS6ST2 VGNC VGNC:73422
Bos taurus HS6ST2 VGNC VGNC:106774
Others HS6ST2 NCBI