2. Gene
  3. SHF - Src homology 2 domain containing F Gene

SHF - Src homology 2 domain containing F Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 90525 | Gene type: protein coding

About SHF

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,167,214-45,201,116 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 4.2), ovary (RPKM 4.0) and 23 other tissues.

Summary

Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Apr 2022]

SHF Products(17)

mRNA Protein Name
NM_001301168.2 NP_001288097.2 SH2 domain-containing adapter protein F isoform a
NM_001301169.2 NP_001288098.2 SH2 domain-containing adapter protein F isoform c
NM_001301170.2 NP_001288099.2 SH2 domain-containing adapter protein F isoform d
NM_001301171.2 NP_001288100.2 SH2 domain-containing adapter protein F isoform e
NM_001394037.1 NP_001380966.1 SH2 domain-containing adapter protein F isoform f
NM_001394038.1 NP_001380967.1 SH2 domain-containing adapter protein F isoform g
NM_001394039.1 NP_001380968.1 SH2 domain-containing adapter protein F isoform h
NM_001394040.1 NP_001380969.1 SH2 domain-containing adapter protein F isoform i
NM_001394041.1 NP_001380970.1 SH2 domain-containing adapter protein F isoform j
NM_001394042.1 NP_001380971.1 SH2 domain-containing adapter protein F isoform k
NM_001394043.1 NP_001380972.1 SH2 domain-containing adapter protein F isoform l
NM_001394044.1 NP_001380973.1 SH2 domain-containing adapter protein F isoform m
NM_001394045.1 NP_001380974.1 SH2 domain-containing adapter protein F isoform n
NM_001394046.1 NP_001380975.1 SH2 domain-containing adapter protein F isoform o
NM_001394047.1 NP_001380976.1 SH2 domain-containing adapter protein F isoform p
NM_001394048.1 NP_001380977.1 SH2 domain-containing adapter protein F isoform q
NM_138356.3 NP_612365.3 SH2 domain-containing adapter protein F isoform b

SHF Protein Structure

SH2

SH2: SH2 domain (323 - 399)

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  • 100
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  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing adapter protein F

CTD-2651B20.7

Related Diseases

Diseases Alias
Enamel Erosion
Tooth Erosion

Generalized Erosion

Localized Erosion

Generalized Erosions

Erosion, Localized
Pyosalpinx

Pyosalpingitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12863 SHF Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SHF VGNC VGNC:34596
Rattus norvegicus SHF RGD RGD:1562705
Mus musculus SHF MGD MGI:3613669
Canis familiaris SHF VGNC VGNC:59130
Felis catus SHF VGNC VGNC:80846
Macaca mulatta SHF VGNC VGNC:99239