METTL18 - methyltransferase like 18 Gene

Also Known as HPM1; AsTP2; C1orf156

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92342

About METTL18

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,792,529-169,794,907 (from NCBI)

This gene has 3 transcripts (splice variants) and 185 orthologues. Ubiquitous expression in lymph node (RPKM 4.6), thyroid (RPKM 3.3) and 25 other tissues.

Summary

Enables heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Located in cytosol and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL18 Products (3)

mRNA Protein Name
NM_001320199.2 NP_001307128.1 histidine protein methyltransferase 1 homolog
NM_001320201.2 NP_001307130.1 histidine protein methyltransferase 1 homolog
NM_033418.4 NP_219486.1 histidine protein methyltransferase 1 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
23349634 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23349634 GOA
enables protein-L-histidine N-tele-methyltransferase activity IDA
IDA: Inferred from direct assay
33693809 GOA
Biological Process GO Annotation Evidence References Source
involved in peptidyl-lysine monomethylation IDA
IDA: Inferred from direct assay
33693809 GOA
involved in regulation of rRNA processing IMP
IMP: Inferred from mutant phenotype
33693809 GOA
involved in regulation of ribosome biogenesis IMP
IMP: Inferred from mutant phenotype
33693809 GOA
involved in regulation of translation IMP
IMP: Inferred from mutant phenotype
33693809 GOA
involved in regulation of translational elongation IDA
IDA: Inferred from direct assay
35674491 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
33693809 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
33693809 GOA
located in nucleus IDA
IDA: Inferred from direct assay
33693809 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL18 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (187 - 238)

Methyltransf_16

Methyltransf_16: Lysine methyltransferase (286 - 325)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

histidine protein methyltransferase 1 homolog

  • arsenic-transactivated protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08359 METTL18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus METTL18 VGNC VGNC:31405
Rattus norvegicus METTL18 RGD RGD:1306783
Macaca mulatta METTL18 VGNC VGNC:74606
Felis catus METTL18 VGNC VGNC:82405
Mus musculus METTL18 MGD MGI:1917212
Canis familiaris METTL18 VGNC VGNC:43173
Others METTL18 NCBI