2. Gene
  3. METTL18 - methyltransferase like 18 Gene

METTL18 - methyltransferase like 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HPM1; AsTP2; C1orf156

Gene ID: 92342 | Gene type: protein coding

About METTL18

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,792,529-169,794,907 (from NCBI)

This gene has 3 transcripts (splice variants) and 185 orthologues. Ubiquitous expression in lymph node (RPKM 4.6), thyroid (RPKM 3.3) and 25 other tissues.

Summary

Enables heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Located in cytosol and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL18 Products(3)

mRNA Protein Name
NM_001320199.2 NP_001307128.1 histidine protein methyltransferase 1 homolog
NM_001320201.2 NP_001307130.1 histidine protein methyltransferase 1 homolog
NM_033418.4 NP_219486.1 histidine protein methyltransferase 1 homolog

METTL18 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (187 - 238)

Methyltransf_16

Methyltransf_16: Lysine methyltransferase (286 - 325)

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  • 372 a.a.
Protein Preferred Names Protein Names

histidine protein methyltransferase 1 homolog

arsenic-transactivated protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08359 METTL18 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus METTL18 VGNC VGNC:31405
Rattus norvegicus METTL18 RGD RGD:1306783
Macaca mulatta METTL18 VGNC VGNC:74606
Felis catus METTL18 VGNC VGNC:82405
Mus musculus METTL18 MGD MGI:1917212
Canis familiaris METTL18 VGNC VGNC:43173