NRXN2 - neurexin 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9379

About NRXN2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,606,174-64,723,197 (from NCBI)

This gene has 20 transcripts (splice variants), 291 orthologues, 35 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 25.4), testis (RPKM 3.9) and 2 other tissues.

Summary

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

NRXN2 Products (10)

mRNA	Protein	Name
NM_001376262.1	NP_001363191.1	neurexin-2-beta isoform 4 precursor
NM_001376263.1	NP_001363192.1	neurexin-2-beta isoform 5 precursor
NM_001376265.1	NP_001363194.1	neurexin-2-beta isoform 7 precursor
NM_001376266.1	NP_001363195.1	neurexin-2-beta isoform 6 precursor
NM_001376267.1	NP_001363196.1	neurexin-2-beta isoform 8 precursor
NM_001400681.1	NP_001387610.1	neurexin-2-beta isoform 9
NM_001400682.1	NP_001387611.1	neurexin-2-beta isoform 10
NM_015080.4	NP_055895.1	neurexin-2-beta isoform alpha-1 precursor
NM_138732.3	NP_620060.1	neurexin-2-beta isoform alpha-2 precursor
NM_138734.3	NP_620063.1	neurexin-2-beta isoform beta precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in adult behavior	IMP IMP: Inferred from mutant phenotype	21424692	GOA
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21424692	GOA
involved in vocal learning	IMP IMP: Inferred from mutant phenotype	21424692	GOA
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	21424692	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRXN2 Protein Structure

Laminin_G_2

Syndecan

0
300
600
900
1200
1500
1712 a.a.

Protein Preferred Names	Protein Names
neurexin-2-beta	neurexin II

Related Diseases

Diseases	Alias
Pitt-Hopkins-Like Syndrome 2	PTHSL2 Mesh D006985 Mesh D008607
Pitt-Hopkins-Like Syndrome 1	Cortical Dysplasia-Focal Epilepsy Syndrome CDFES PTHSL1 Cdfe Syndrome Pitt-Hopkins Like Syndrome 1 Pitt-Hopkins-Like Syndrome-1 Cntnap2-Related Developmental And Epileptic Encephalopathy Cntnap2-Related Dee Mesh D006985 Mesh D008607
Childhood Disintegrative Disease	Childhood Disintegrative Disorder Disintegrative Psychosis Heller'S Syndrome Symbiotic Psychosis Dementia Infantilis Heller Syndrome Shared Paranoid Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Tic Disorder	Tics Behavioral Tic
Syndromic X-Linked Intellectual Disability Najm Type	Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia Micpch X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Phelan-Mcdermid Syndrome	Chromosome 22q13.3 Deletion Syndrome 22q13.3 Deletion Syndrome Telomeric 22q13 Monosomy Syndrome PHMDS Deletion 22q13 Syndrome 22q13.3 Deletion Deletion 22q13.3 Syndrome Monosomy 22q13 Monosomy 22q13.3 22q13 Deletion Syndrome Monosomy 22q13 Syndrome 22q13 Deletion Chromosome Deletion
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Pitt-Hopkins Syndrome	PTHS Encephalopathy, Severe Epileptic, With Autonomic Dysfunction Mental Retardation, Syndromal, With Intermittent Hyperventilation Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea Pitt Hopkins Syndrome Phs Encephalopathy Severe Epileptic With Autonomic Dysfunction
Specific Developmental Disorder
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Syndromic Intellectual Disability
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09584	NRXN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21670	Nrxn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28188	Nrxn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NRXN2	VGNC	VGNC:32271
Felis catus	NRXN2	VGNC	VGNC:104316
Canis familiaris	NRXN2	VGNC	VGNC:43979
Rattus norvegicus	NRXN2	RGD	RGD:620211
Macaca mulatta	NRXN2	VGNC	VGNC:75534
Mus musculus	NRXN2	MGD	MGI:1096362
Others	NRXN2	NCBI