ARHGAP12 - Rho GTPase activating protein 12 Gene

Homo sapiens

Gene ID: 94134 | Gene type: protein coding

About ARHGAP12

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:31,805,398-31,928,876 (from NCBI)

This gene has 10 transcripts (splice variants), 276 orthologues and 3 paralogues. Ubiquitous expression in stomach (RPKM 14.4), brain (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

ARHGAP12 Products(6)

mRNA	Protein	Name
NM_001270695.1	NP_001257624.1	rho GTPase-activating protein 12 isoform 2
NM_001270696.2	NP_001257625.1	rho GTPase-activating protein 12 isoform 3
NM_001270697.1	NP_001257626.1	rho GTPase-activating protein 12 isoform 4
NM_001270698.2	NP_001257627.1	rho GTPase-activating protein 12 isoform 5
NM_001270699.1	NP_001257628.1	rho GTPase-activating protein 12 isoform 6
NM_018287.7	NP_060757.4	rho GTPase-activating protein 12 isoform 1

ARHGAP12 Protein Structure

SH3_9

RhoGAP

0
200
400
600
800
846 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 12

rho-type GTPase-activating protein 12

Related Diseases

Diseases

Alias

Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome	Shah-Waardenburg Syndrome
Waardenburg Syndrome Type 4a	WS4A
Ws4	Waardenburg Syndrome Type 4
Waardenburg Syndrome Type Iva	Waardenburg Syndrome With Hirschsprung Disease Type 4a
Hirschsprung Disease With Pigmentary Anomaly	Waardenburg-Hirschsprung Syndrome
Waardenburg Syndrome, Type Iva	Waardenburg Syndrome With Hirschsprung Disease, Type 4a
Waardenburg-Hirschsprung Disease	Waardenburg Syndrome, Type 4
Waardenburg Syndrome 4a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00915	ARHGAP12 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGAP12	VGNC	VGNC:38046
Felis catus	ARHGAP12	VGNC	VGNC:59875
Rattus norvegicus	ARHGAP12	RGD	RGD:1310017
Bos taurus	ARHGAP12	VGNC	VGNC:26075
Macaca mulatta	ARHGAP12	VGNC	VGNC:69842
Mus musculus	ARHGAP12	MGD	MGI:1922665

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