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FARP2 - FERM, ARH/RhoGEF and pleckstrin domain protein 2 Gene

Also Known as FIR; FRG; PLEKHC3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9855

About FARP2

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,356,285-241,494,841 (from NCBI)

This gene has 23 transcripts (splice variants), 215 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 7.0), skin (RPKM 5.6) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within Rac protein signal transduction and neuron remodeling. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FARP2 Products (3)

mRNA	Protein	Name
NM_001282983.2	NP_001269912.1	FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b
NM_001282984.2	NP_001269913.1	FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform c
NM_014808.4	NP_055623.1	FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	12351724	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Rac protein signal transduction	IDA IDA: Inferred from direct assay	12351724	GOA
acts upstream of or within neuron remodeling	IDA IDA: Inferred from direct assay	12351724	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12351724	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARP2 Protein Structure

FERM_N

FERM_M

FERM_C

RhoGEF

0
200
400
600
800
1000
1054 a.a.

Protein Preferred Names	Protein Names
FERM, ARHGEF and pleckstrin domain-containing protein 2	FERM domain including RhoGEF

Related Diseases

Diseases	Alias
Chromosome 2q37 Deletion Syndrome	Albright Hereditary Osteodystrophy-Like Syndrome 2q37 Microdeletion Syndrome Brachydactyly-Intellectual Disability Syndrome Deletion 2q37 2q37 Deletion Syndrome Brachydactyly-Mental Retardation Syndrome Bdmr Albright Hereditary Osteodystrophy Type 3 Del(2)(Q37) Monosomy 2q37qter Albright'S Hereditary Osteodystrophy-Like Syndrome Monosomy 2q37 Chromosome Deletion Syndrome 2q37
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome
Parkinson Disease 6, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 6 Parkinson Disease 6 PARK6 Parkinson Disease 6, Early Onset Parkinson'S Disease 6 Parkinson Disease 6, Early-Onset Autosomal Recessive Early-Onset Parkinson'S Disease 6 Early-Onset Parkinson Disease 6 Autosomal Recessive Early-Onset Parkinson Disease Type 6 Parkinson Disease 6 Early-Onset Parkinson Disease 6 Late-Onset Susceptibility To Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1 Parkinsonism Young Adult Onset Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1 Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Pathologic Nystagmus	Nystagmus
Congenital Nystagmus	Nystagmus, Congenital Nystagmus Congenital
Hermansky-Pudlak Syndrome 1	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells HPS1 Delta Storage Pool Disease Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Hermansky-Pudlak Syndrome, Type 1 Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04747	FARP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FARP2	VGNC	VGNC:62150
Canis familiaris	FARP2	VGNC	VGNC:40731
Macaca mulatta	FARP2	VGNC	VGNC:72513
Rattus norvegicus	FARP2	RGD	RGD:1308003
Mus musculus	FARP2	MGD	MGI:2385126
Bos taurus	FARP2	VGNC	VGNC:55172
Others	FARP2	NCBI