TAS1R3 - taste 1 receptor member 3 Gene

Also Known as T1R3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83756

About TAS1R3

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,331,280-1,335,314 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues.

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

TAS1R3 Products (1)

mRNA Protein Name
NM_152228.3 NP_689414.2 taste receptor type 1 member 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to sweet taste receptor activity IDA
IDA: Inferred from direct assay
16720576 GOA
contributes to taste receptor activity IDA
IDA: Inferred from direct assay
16720576 GOA
enables taste receptor activity IPI
IPI: Inferred from physical interaction
11917125 GOA
Biological Process GO Annotation Evidence References Source
involved in detection of chemical stimulus involved in sensory perception of sweet taste IDA
IDA: Inferred from direct assay
16720576 GOA
involved in sensory perception of sweet taste IDA
IDA: Inferred from direct assay
11917125 GOA
involved in sensory perception of umami taste IDA
IDA: Inferred from direct assay
11917125 GOA
Cellular Component GO Annotation Evidence References Source
part of sweet taste receptor complex IDA
IDA: Inferred from direct assay
16720576 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAS1R3 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (72 - 462)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (495 - 547)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (581 - 817)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 852 a.a.
Protein Preferred Names Protein Names

taste receptor type 1 member 3

  • sweet taste receptor T1R3

Related Diseases

Diseases Alias
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Renal Pelvis Transitional Cell Carcinoma

  • Urothelial Cell Carcinoma Of Renal Pelvis

  • Renal Pelvis Urothelial Carcinoma

  • Transitional Cell Carcinoma Of Renal Pelvis
Glucocorticoid Deficiency 1

  • Acth Resistance

  • Glucocorticoid Deficiency, Due To Acth Unresponsiveness

  • GCCD1

  • Familial Glucocorticoid Deficiency 1

  • Fgd1

  • Adrenal Unresponsiveness To Acth

  • Hereditary Unresponsiveness To Adrenocorticotropic Hormone

  • Isolated Glucocorticoid Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0467 Rebaudioside C 99.99% Unkown
HY-RS14214 TAS1R3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21204 Tas1r3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27720 Tas1r3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TAS1R3 VGNC VGNC:47113
Macaca mulatta TAS1R3 VGNC VGNC:106513
Bos taurus TAS1R3 VGNC VGNC:106965
Rattus norvegicus TAS1R3 RGD RGD:620539
Felis catus TAS1R3 VGNC VGNC:80375
Mus musculus TAS1R3 MGD MGI:1933547
Others TAS1R3 NCBI