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Cat. No.: HY-119125

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BMS-317180

BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC₅₀=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia.

For research use only. We do not sell to patients.

CAS No.: 295337-71-2
Formula: C₂₁H₃₃N₇O₅
Molecular Weight:463.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BMS-317180 Chemical Structure

CAS No.: 295337-71-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All GHSR Isoforms :

GHSR1a

Cellular Effect

Cell Line	Type	Value	Description	References
H4	EC₅₀	1.9 nM Compound: 2, BMS-317180	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	[PMID: 17973363]
H4	EC₅₀	1.9 nM Compound: 4, BMS-317180	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	[PMID: 18378446]

Chemical Information

CAS No. 295337-71-2
Molecular Weight 463.53
Formula C₂₁H₃₃N₇O₅
SMILES

O=C(NCCCCO)OCCN1N=NN=C1[C@@H](COCC2=CC=CC=C2)NC(C(N)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li J, et al. Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180). J Med Chem. 2007 Nov 29;50(24):5890-3. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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