Tetrazole based amides as growth hormone secretagogues

  • Bioorg Med Chem Lett. 2008 Apr 15;18(8):2536-9. doi: 10.1016/j.bmcl.2008.03.059.
James J Li  1 ,  Haixia Wang ,  Jun Li ,  Fucheng Qu ,  Stephen G Swartz ,  Andrés S Hernández ,  Scott A Biller ,  Jeffrey A Robl ,  Joseph A Tino ,  Dorothy Slusarchyk ,  Ramakrishna Seethala ,  Paul Sleph ,  Mujing Yan ,  Gary Grover ,  Neil Flynn ,  Brian J Murphy ,  David Gordon
Affiliations
  • 1. Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543-5400, USA. [email protected]
PMID: 18378446 DOI: 10.1016/j.bmcl.2008.03.059
Abstract

A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.