Tet1 peptide
Based on 1 Customer Validation
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research.
For research use only. We do not sell to patients.
- CAS No.: 270919-17-0
- Formula: C73H114N20O17
- Molecular Weight:1543.81
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tet1 peptide conjugated with PEGylated poly(2-(N,N-dimethylamino)ethyl methacrylate) (PEG-PDMAEMA) forms siRNA nanocomplexes capable of achieving specific siRNA delivery to neurons[1].
Tet1 peptide functionalized on polymersomes and administered via cochleostomy mediates targeting of the polymersomes to the rat cochlear nerve; however, no targeting effect was observed following transtympanic injection.[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tet1 peptide-modified CT/siRNA nanocomplexes (32 μg siRNA per mouse; i.v.; single dose) deliver siRNA to the brain of healthy ICR mice with a DTI of 2.62 and peak accumulation of 2.42 %ID/g-brain at 1 hour post-injection[1].
Tet1 peptide-modified CT/BACE1-siRNA nanocomplexes (80 μg siRNA per mouse; i.v.; every 5 days; 4 total doses) restore cognitive performance to wild-type levels, reduce BACE1 mRNA by ~27.6%, lower amyloid plaque burden by ~87.5%, and protect neurons while promoting neurogenesis in 8-month-old APP/PS1 Alzheimer's disease model mice[1].
Tet1 peptide-functionalized PEG-b-PCL polymersomes (40-100 µL; transtympanic injection, bilateral; cochleostomy, unilateral, via osmotic pump connected to scala tympani; single dose; 3 days duration) uniquely target tractus spiralis foraminosus region nerve fibers when delivered via cochleostomy, while sharing non-specific inner ear tissue distribution with control polymersomes across both delivery routes, and do not target the cochlear nerve via transtympanic injection (a pattern consistent across all PM types)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
His-Leu-Asn-Ile-Leu-Ser-Thr-Leu-Trp-Lys-Tyr-Arg
HLNILSTLWKYR
Chemical Information
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CAS No. 270919-17-0
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Appearance Solid
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Molecular Weight 1543.81
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Formula C73H114N20O17
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (64.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang P, et al. Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease. J Control Release. 2018;279:220-233. [Content Brief]
[2]. Zhang Y, et al. Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. Int J Nanomedicine. 2012;7:1015-1022. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6477 mL | 3.2387 mL | 6.4775 mL | 16.1937 mL |
| 5 mM | 0.1295 mL | 0.6477 mL | 1.2955 mL | 3.2387 mL | |
| 10 mM | 0.0648 mL | 0.3239 mL | 0.6477 mL | 1.6194 mL | |
| 15 mM | 0.0432 mL | 0.2159 mL | 0.4318 mL | 1.0796 mL | |
| 20 mM | 0.0324 mL | 0.1619 mL | 0.3239 mL | 0.8097 mL | |
| 25 mM | 0.0259 mL | 0.1295 mL | 0.2591 mL | 0.6477 mL | |
| 30 mM | 0.0216 mL | 0.1080 mL | 0.2159 mL | 0.5398 mL | |
| 40 mM | 0.0162 mL | 0.0810 mL | 0.1619 mL | 0.4048 mL | |
| 50 mM | 0.0130 mL | 0.0648 mL | 0.1295 mL | 0.3239 mL | |
| 60 mM | 0.0108 mL | 0.0540 mL | 0.1080 mL | 0.2699 mL |
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