CRYBA4 - crystallin beta A4 Gene

Also Known as CYRBA4; CTRCT23; MCOPCT4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1413

About CRYBA4

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:26,590,220-26,630,669 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues, 14 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with Other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]

CRYBA4 Products (1)

mRNA	Protein	Name
NM_001886.3	NP_001877.1	beta-crystallin A4

CRYBA4 Protein Structure

Crystall

0
100
196 a.a.

Protein Preferred Names	Protein Names
beta-crystallin A4	beta crystallin A4 chain transcript PS

CRYBA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRYBA4	P53673	GLI1	Homo sapiens	P08151	Validated Y2H	25910212
Intra	CRYBA4	P53673	GLI1	Homo sapiens	P08151	Y2H Array	25910212
Intra	CRYBA4	P53673	GLI1	Homo sapiens	P08151	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	EFEMP1	Homo sapiens	Q12805	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	EFEMP1	Homo sapiens	Q12805	Validated Y2H	25910212
Intra	CRYBA4	P53673	EFEMP1	Homo sapiens	Q12805	Y2H Array	25910212
Intra	CRYBA4	P53673	STX11	Homo sapiens	O75558	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	STX11	Homo sapiens	O75558	Validated Y2H	25910212
Intra	CRYBA4	P53673	STX11	Homo sapiens	O75558	Y2H Array	25910212
Intra	CRYBA4	P53673	CCDC33	Homo sapiens	Q8N5R6	Validated Y2H	25910212
Intra	CRYBA4	P53673	CCDC33	Homo sapiens	Q8N5R6	Y2H Array	25910212
Intra	CRYBA4	P53673	CCDC33	Homo sapiens	Q8N5R6	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	TRIP6	Homo sapiens	Q15654	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	TRIP6	Homo sapiens	Q15654	Validated Y2H	25910212
Intra	CRYBA4	P53673	TRIP6	Homo sapiens	Q15654	Y2H Array	25910212
Intra	CRYBA4	P53673	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	25910212
Intra	CRYBA4	P53673	CEP76	Homo sapiens	Q8TAP6	Y2H Array	25910212
Intra	CRYBA4	P53673	CEP76	Homo sapiens	Q8TAP6	Y2H Array	25416956
Intra	CRYBA4	P53673	CEP76	Homo sapiens	Q8TAP6	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25910212
Intra	CRYBA4	P53673	IKZF3	Homo sapiens	Q9UKT9	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25910212
Intra	CRYBA4	P53673	FHL5	Homo sapiens	Q5TD97	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	FHL5	Homo sapiens	Q5TD97	Validated Y2H	25910212
Intra	CRYBA4	P53673	FHL5	Homo sapiens	Q5TD97	Y2H Array	25910212
Intra	CRYBA4	P53673	CRYBB1	Homo sapiens	P53674	Pull Down	31254514
Intra	CRYBA4	P53673	CRYBB1	Homo sapiens	P53674	Y2H	31254514
Intra	CRYBA4	P53673	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25910212
Intra	CRYBA4	P53673	CRYBA4	Homo sapiens	P53673	Y2H	31254514
Intra	CRYBA4	P53673	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25910212
Intra	CRYBA4	P53673	C1orf94	Homo sapiens	Q6P1W5	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	CRYBA4	Homo sapiens	P53673	FCS	31254514
Intra	CRYBA4	P53673	CRYBA4	Homo sapiens	P53673	Crosslink	31254514
Intra	CRYBA4	P53673	CRYBA4	Homo sapiens	P53673	GMS	31254514
Intra	CRYBA4	P53673	MIF4GD	Homo sapiens	A9UHW6-2	Validated Y2H	25910212
Intra	CRYBA4	P53673	MIF4GD	Homo sapiens	A9UHW6-2	Y2H Bait-Prey Pool	25910212
Intra	CRYBA4	P53673	MIF4GD	Homo sapiens	A9UHW6-2	Y2H Array	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 23, Multiple Types	Cataract 23 CTRCT23 Lamellar Cataract 23 Cataract 23, Multiple Types, With Or Without Microcornea Isolated Microphthalmia With Cataract 4 Mcopct4 Cataract, Type 23 Microphthalmia, Isolated, With Cataract 4
Cataract 17, Multiple Types	CTRCT17 Cataract, Congenital Nuclear, Autosomal Recessive 3 Catcn3 Cataract 17 Multiple Types Cataract 17, Multiple Types, With Or Without Microcornea Autosomal Recessive Congenital Nuclear Cataract 3
Cataract Microcornea Syndrome	Microcornea Cataract Syndrome Cataract-Microcornea Syndrome
Early-Onset Lamellar Cataract
Colobomatous Microphthalmia	Anophthalmia-Microphthalmia Syndrome Mac Microphthalmia With Colobomatous Cyst Microphthalmia-Anophthalmia-Coloboma Syndrome Microphthalmia-Anophthalmia-Coloboma Microphthalmia And Mental Deficiency
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Trichothiodystrophy 6, Nonphotosensitive	TTD6 Nonphotosensitive Trichothiodystrophy 6 Trichothiodystrophy 6, Non-Photosensitive
Nonphotosensitive Trichothiodystrophy	Trichothiodystrophy Nonphotosensitive Amish Brittle Hair Brain Syndrome
Abruzzo-Erickson Syndrome	Abruzzo Erickson Syndrome ABERS Charge-Like Syndrome, X-Linked Cleft Palate-Coloboma-Deafness Syndrome Charge Like Syndrome X-Linked Charge-Like Syndrome Cleft Palate-Coloboma-Hearing Loss Syndrome X-Linked Charge-Like Syndrome
Nance-Horan Syndrome	NHS Cataract-Dental Syndrome Cataract, X-Linked, With Hutchinsonian Teeth Mesiodens-Cataract Syndrome Cataract X-Linked With Hutchinsonian Teeth Cataract Dental Syndrome Mesiodens Cataract Syndrome
Posterior Polar Cataract	Cataract, Posterior Polar
Retinitis Pigmentosa 29	RP29
Isolated Microphthalmia
Galactosemia Ii	Galactokinase Deficiency Galk Deficiency Galactokinase Deficiency With Cataracts Deficiency Of Galactokinase GALAC2 Galk-D Galactokinase Deficiency Galactosemia Galactosemia 2 Galactosemia Type 2 Hereditary Galactokinase Deficiency Galactokinase Deficiency, Cataract Galactosemias Galk - [Galactokinase Deficiency]
Syndromic Microphthalmia	Microphthalmia, Syndromic
Microphthalmia, Syndromic 2	Oculofaciocardiodental Syndrome Ofcd Syndrome MCOPS2 Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects Syndromic Microphthalmia 2 Anop2 Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome Maa2 Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects Syndromic Microphthalmia Type 2 Oculo-Facio-Cardio-Dental Syndrome Anop2, Formerly Maa2, Formerly Microphthalmia Syndromic 2 Oculo Facio Cardio Dental Syndrome Microphthalmia, Syndromic, 2 Marashi-Gorlin Syndrome Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects Microphthalmia, Syndromic, Type 2
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Porencephaly
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Lens Disease	Lens Diseases
Lens Subluxation	Subluxation Of Lens
Anterior Segment Dysgenesis	Anterior Segment Developmental Anomaly Anterior Segment Mesenchymal Dysgenesis Corneal Opacification And Other Ocular Anomalies Sclerocornea With Other Ocular Anomalies Asmd Asod Anterior Segment Ocular Dysgenesis Foxe3-Related Ocular Disorder Familial Ocular Anterior Segment Mesenchymal Dysgenesis Dysgenesis, Anterior Segment Irido-Corneal Dysgenesis Axenfeld-Rieger Syndrome, Type 3
Iris Disease	Iris Diseases
Amblyopia	Lazy Eye
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03209	CRYBA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CRYBA4	MGD	MGI:102716
Felis catus	CRYBA4	VGNC	VGNC:61200
Bos taurus	CRYBA4	VGNC	VGNC:27735
Macaca mulatta	CRYBA4	VGNC	VGNC:71503
Rattus norvegicus	CRYBA4	RGD	RGD:61962
Canis familiaris	CRYBA4	VGNC	VGNC:39638
Others	CRYBA4	NCBI