GLI1 - GLI family zinc finger 1 Gene

Also Known as GLI; PPD1; PAPA8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2735

About GLI1

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,459,785-57,472,268 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues, 14 paralogues and is associated with 98 phenotypes. Broad expression in endometrium (RPKM 5.6), testis (RPKM 2.9) and 15 other tissues.

Summary

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic Hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GLI1 Products (5)

mRNA	Protein	Name
NM_001160045.2	NP_001153517.1	zinc finger protein GLI1 isoform 2
NM_005269.3	NP_005260.1	zinc finger protein GLI1 isoform 1
XM_011538190.3	XP_011536492.1	zinc finger protein GLI1 isoform X2
XM_011538189.3	XP_011536491.1	zinc finger protein GLI1 isoform X1
NM_001167609.2	NP_001161081.1	zinc finger protein GLI1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9118802	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18298960	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	19706761	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10564661	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19706761	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17035233	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in epidermal cell differentiation	IDA IDA: Inferred from direct assay	12165851	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17035233	GOA
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	12165851	GOA
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	12165851	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11238441	GOA
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	28583401	GOA
involved in positive regulation of cell cycle G1/S phase transition	IDA IDA: Inferred from direct assay	28583401	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	19706761	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12165851	GOA
involved in positive regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	17035233	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9118802	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12165851	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24311597	GOA
involved in smoothened signaling pathway	IDA IDA: Inferred from direct assay	19878745	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of GLI-SUFU complex	IPI IPI: Inferred from physical interaction	24311597	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	24076122	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10504446	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18559511	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10806483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLI1 Protein Structure

zf-H2C2_2

zf-C2H2

0
200
400
600
800
1000
1106 a.a.

Protein Preferred Names	Protein Names
zinc finger protein GLI1	GLI-Kruppel family member GLI1 glioma-associated oncogene 1 glioma-associated oncogene homolog 1 (zinc finger protein) oncogene GLI

GLI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GLI1	P08151	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	GLI1	P08151	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	20818436
Intra	GLI1	P08151	RPS6KB1	Homo sapiens	P23443	Anti Bait CoIP	22439934
Intra	GLI1	P08151	VHL	Homo sapiens	P40337-3	Anti Tag CoIP	23395608
Cross	GLI1	P08151	Zic1	Mus musculus	P46684	Pull Down	11238441
Cross	GLI1	P08151	Zic1	Mus musculus	P46684	Anti Tag CoIP	11238441
Intra	GLI1	P08151	VHL	Homo sapiens	P40337-1	Anti Tag CoIP	23395608
Cross	GLI1	P08151	Numb	Mus musculus	Q9QZS3-2	Anti Tag CoIP	20818436
Cross	GLI1	P08151	Numb	Mus musculus	Q9QZS3-2	Pull Down	20818436
Intra	GLI1	P08151	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	GLI1	P08151	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
Intra	GLI1	P08151	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	Y2H Array	20211142
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	SAXS	24311597
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	MST	24311597
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	TAP	25609649
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	TSA	24311597
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	24311597
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	PLA	25241761
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	Anti Bait CoIP	22439934
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	Pull Down	24217340
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1	X-Ray Diffraction	24311597
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1-1	Anti Tag CoIP	10564661
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1-2	Pull Down	10564661
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1-2	Anti Tag CoIP	10564661
Intra	GLI1	P08151	SUFU	Homo sapiens	Q9UMX1-2	IF	10564661
Intra	GLI1	P08151	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	GLI1	P08151	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	GLI1	P08151	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	32296183
Intra	GLI1	P08151	GCC1	Homo sapiens	Q96CN9	Validated Y2H	25416956
Intra	GLI1	P08151	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	25416956
Intra	GLI1	P08151	GCC1	Homo sapiens	Q96CN9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

GLI1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83731	Gli1 Antibody	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
HY-P84001	Gli1 Antibody (YA3698)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84001A	Gli1 Antibody (YA3698)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Cerebellar Medulloblastoma
Ameloblastoma	Adenoameloblastoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Basosquamous Carcinoma	Carcinoma, Basosquamous Basisquamous Cell Carcinoma Basosquamous Cell Carcinoma Metatypical Carcinoma
Glioma
Rhabdomyosarcoma
Cerebellum Cancer	Cerebellar Neoplasms Cerebellar Cancer Malignant Tumor Of Cerebellum Malignant Neoplasm Of Cerebellum
Fibroepithelial Basal Cell Carcinoma	Fibroepithelioma Of Pinkus Fibroepithelioma Of Pinkus Type Pinkus Tumor
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Polydactyly, Postaxial, Type A8	PAPA8 Polydactyly, Postaxial, A8
Acrocapitofemoral Dysplasia	ACFD Dysplasia, Acrocapitofemoral
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Greig Cephalopolysyndactyly Syndrome	GCPS Polysyndactyly With Peculiar Skull Shape Polysyndactyly With Peculiars Skull Shape Greig Syndrome Cephalopolysyndactyly Syndrome Greig Cephalo-Poly-Syndactyly Syndrome Cephalopolysyndactyly, Greig Syndrome Aarskog Syndrome
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Penis Carcinoma In Situ	Carcinoma In Situ Of Penis Bowen'S Disease Of Penis Grade Iii Squamous Intraepithelial Lesion Of Penis Penile Intraepithelial Neoplasia Grade Iii Queyrat'S Erythroplasia Erythroplasia Of Queyrat Pin - [Penile Intraepithelial Neoplasia]
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Polydactyly, Preaxial I	PPD1 Thumb Polydactyly Polydactyly Of A Biphalangeal Thumb Polydactyly, Preaxial Preaxial Polydactyly Type 1 Polydactyly Preaxial 1 Preaxial Polydactyly 1 Polydactyly Preaxial Type 1 Polydactyly, Preaxial 1 Preaxial Polydactyly Accessory Thumb Supernumerary Thumb Extra Thumb
Chondroma	Central Chondroma Enchondroma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Granuloma Annulare	Granulome Annulare Ga - [Granuloma Annulare]
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Syndactyly, Type I Sd1 Zygodactyly Syndactyly, Type 1, With Or Without Craniosynostosis Non-Syndromic Syndactyly Symphalangism Symphalangy Webbing Of Digits Syndactyly, Type 1
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Meckel Syndrome, Type 1	Meckel Syndrome Meckel-Gruber Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Polydactyly, Postaxial, Type A1	Postaxial Polydactyly Type A Polydactyly, Postaxial Postaxial Polydactyly PAPA1 Postaxial Polydactyly, Type A Papa Polydactyly, Postaxial, Types A1 And B Postaxial Polydactyly Type B Polydactyly Postaxial Polydactyly, Postaxial A1 Polydactyly, Postaxial B PAPB Postaxial Polydactyly, Type A1/B Polydactyly, Postaxial, Type A Pyogenic Arthritis, Pyoderma Gangrenosum And Acne Postaxial Polydactyly, Type B
Pericytoma With T(7;12)
Focal Dermal Hypoplasia	Goltz Syndrome Goltz-Gorlin Syndrome FDH FODH Dhof Goltz Gorlin Syndrome Hypoplasia, Dermal, Focal
Anus, Imperforate	Imperforate Anus Anal Atresia Anorectal Malformations Anorectal Malformation Congenital Atresia Of Anus Congenital Or Infantile Occlusion Of Anus Anal Stenosis Arm
Ellis-Van Creveld Syndrome	Chondroectodermal Dysplasia Mesoectodermal Dysplasia EVC Ellis Van Creveld Syndrome Mesodermic Dysplasia Ellis-Van Creveld Dysplasia
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Necrobiosis Lipoidica	Oppenheim-Urbach Disease Necrobiosis Lipoidica Diabeticorum
Apert Syndrome	Acrocephalosyndactyly Type I Acs1 Acrocephalosyndactylia Acs I Apert-Crouzon Disease Acrocephalosyndactyly Acrocephalosyndactyly Type 1 Acrocephalosyndactyly, Type I Acs 1 Acrocephalo-Syndactyly Type 1 Syndactylic Oxycephaly Apert'S Syndrome Type I Acrocephalosyndactyly APRS
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Brachydactyly
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Nodular Medulloblastoma	Medulloblastoma, With Extensive Nodularity
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Orofacial Cleft	Cleft, Orofacial
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Acrocallosal Syndrome	ACLS Schinzel Acrocallosal Syndrome Joubert Syndrome 12 Schinzel Syndrome 1 Acrocallosal Syndrome, Schinzel Type Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum Acs Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum JBTS12 Acrocallosal Syndrome
Vacterl Association	Vater Association Vater Syndrome
Joubert Syndrome 32	JBTS32
Trachea Leiomyoma	Tracheal Neoplasms Leiomyoma Of The Trachea Tracheal Neoplasm Tracheal Leiomyoma
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13901	GANT 61		99.80%	Unkown
HY-P4860	Adropin (34-76) (human, mouse, rat)		98.23%	Unkown
HY-W269593	Perfluorodecanoic acid	Inhibitor	98.0%	Unkown
HY-13282	GANT 58	Antagonist	99.37%	Unkown
HY-N2112	Glaucocalyxin A		99.88%	Unkown
HY-18366A	RU-SKI 43 hydrochloride	Inhibitor	98.81%	Unkown
HY-122590	Glabrescione B	Inhibitor	98.08%	Unkown
HY-107551	Hh Pathway-IN-1		99.06%	Unkown
HY-107408	SANT 2	Antagonist	99.41%	Unkown
HY-W111144	T-1330	Inhibitor	/	Unkown
HY-18366	RU-SKI 43	Inhibitor	/	Unkown
HY-RS05472	GLI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-137567	Prostaglandin E1 ethanolamide	Activator	/	Unkown
HY-143400	HSP70-IN-3	Inhibitor	/	Unkown
HY-147670	TPB15		/	Unkown
HY-159893	SMO-IN-5		/	Unkown
HY-161459	GLI1-IN-1		/	Unkown
HY-162273	Antibacterial agent 189	Inhibitor	/	Unkown
HY-176056	Hedgehog IN-9		/	Unkown
HY-182641	SAG analog (cis-isomer)	Activator	/	Unkown
HY-183335	SMO-IN-6		/	Unkown
HY-N8270	Physalin H	Inhibitor	/	Unkown
HY-N9684	Degalactotigonin		/	Unkown
HY-RS05473	Gli1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05474	Gli1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05480	GLIS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122017	Methoxy-SANT-2	Antagonist	/	Unkown
HY-172449	GLI1-IN-3	Inhibitor	/	Unkown
HY-W338819	Clobetasol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GLI1	VGNC	VGNC:41256
Felis catus	GLI1	VGNC	VGNC:62578
Macaca mulatta	GLI1	VGNC	VGNC:73069
Rattus norvegicus	GLI1	RGD	RGD:621673
Bos taurus	GLI1	VGNC	VGNC:29399
Mus musculus	GLI1	MGD	MGI:95727
Others	GLI1	NCBI