1. PI3K/Akt/mTOR
    Apoptosis
  2. PI3K
    Akt
    Apoptosis
  3. Glaucocalyxin A

Glaucocalyxin A 

Cat. No.: HY-N2112
Handling Instructions

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect.

For research use only. We do not sell to patients.

Glaucocalyxin A Chemical Structure

Glaucocalyxin A Chemical Structure

CAS No. : 79498-31-0

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Description

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

IC50 & Target[1]

PI3K

 

Akt

 

In Vitro

Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].

Molecular Weight

332.43

Formula

C₂₀H₂₈O₄

CAS No.

79498-31-0

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Keywords:

Glaucocalyxin API3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BInhibitorinhibitorinhibit

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