1. PI3K/Akt/mTOR
    Apoptosis
  2. PI3K
    Akt
    Apoptosis
  3. Glaucocalyxin A

Glaucocalyxin A 

Cat. No.: HY-N2112 Purity: 99.38%
Handling Instructions

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect.

For research use only. We do not sell to patients.

Glaucocalyxin A Chemical Structure

Glaucocalyxin A Chemical Structure

CAS No. : 79498-31-0

Size Price Stock Quantity
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 571 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

IC50 & Target[1]

PI3K

 

Akt

 

In Vitro

Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

332.43

Formula

C₂₀H₂₈O₄

CAS No.

79498-31-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (300.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0082 mL 15.0408 mL 30.0815 mL
5 mM 0.6016 mL 3.0082 mL 6.0163 mL
10 mM 0.3008 mL 1.5041 mL 3.0082 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Glaucocalyxin API3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BInhibitorinhibitorinhibit

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Glaucocalyxin A
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HY-N2112
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