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Smad4 - SMAD family member 4 Gene

Also Known as DPC4; Madh4; D18Wsu70e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17128

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Collagen binding activity; and identical protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; heart development; and positive regulation of protein modification process. Acts upstream of or within several processes, including animal organ development; positive regulation of gonadotropin secretion; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and respiratory system. Used to study juvenile polyposis syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ Cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (Smad Family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smad4 Products (3)

mRNA	Protein	Name
NM_001364967.1	NP_001351896.1	mothers against decapentaplegic homolog 4 isoform 2
NM_001364968.1	NP_001351897.1	mothers against decapentaplegic homolog 4 isoform 3
NM_008540.3	NP_032566.2	mothers against decapentaplegic homolog 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12270938	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19366691	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	21330551	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12943993	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14764653	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21724602	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	21330551	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21330551	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15657445	MGI
enables collagen binding	IPI IPI: Inferred from physical interaction	14559231	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21724602	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12543979	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	16330325	MGI
acts upstream of or within SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	9420335	MGI
involved in SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15215210	MGI
involved in atrioventricular canal development	IGI IGI: Inferred from genetic interaction	21330551	MGI
involved in atrioventricular valve formation	IGI IGI: Inferred from genetic interaction	21330551	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	21300867	MGI
acts upstream of or within brainstem development	IMP IMP: Inferred from mutant phenotype	21300867	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	15925496	MGI
involved in cardiac septum development	IGI IGI: Inferred from genetic interaction	21330551	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	9506519	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	9420335	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	9420335	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	23034633	MGI
involved in endocardial cell differentiation	IMP IMP: Inferred from mutant phenotype	21330551	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	9420335	MGI
involved in endothelial cell activation	IMP IMP: Inferred from mutant phenotype	21330551	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	21330551	MGI
acts upstream of or within female gonad development	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within female gonad morphogenesis	IMP IMP: Inferred from mutant phenotype	24739304	MGI
acts upstream of or within formation of anatomical boundary	IMP IMP: Inferred from mutant phenotype	9420335	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	9420335	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	15215210	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9420335	MGI
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	16330325	MGI
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	16330325	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	15342483	MGI
involved in left ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	16151019	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	24739304	MGI
acts upstream of mesendoderm development	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	9420335	MGI
involved in metanephric mesenchyme morphogenesis	IMP IMP: Inferred from mutant phenotype	15342483	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16151019	MGI
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	16151019	MGI
involved in negative regulation of cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	16151019	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	9506519	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24739304	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16151019	MGI
involved in nephrogenic mesenchyme morphogenesis	IMP IMP: Inferred from mutant phenotype	15342483	MGI
acts upstream of or within neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	19793887	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	17698011	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	17628518	MGI
acts upstream of or within ovarian follicle development	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	24739304	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15282343	MGI
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	14691138	MGI
involved in positive regulation of cell proliferation involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	21330551	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within positive regulation of follicle-stimulating hormone secretion	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within positive regulation of follicle-stimulating hormone secretion	IMP IMP: Inferred from mutant phenotype	24739304	MGI
acts upstream of or within positive regulation of luteinizing hormone secretion	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within positive regulation of luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	24739304	MGI
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	23426367	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9702197	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19366691	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17159989	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18692037	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16330325	MGI
acts upstream of or within regulation of binding	IDA IDA: Inferred from direct assay	15282343	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10708962	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10708962	MGI
acts upstream of or within regulation of hair follicle development	IMP IMP: Inferred from mutant phenotype	18692037	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12270938	MGI
acts upstream of or within sebaceous gland development	IMP IMP: Inferred from mutant phenotype	18692037	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within seminiferous tubule development	IMP IMP: Inferred from mutant phenotype	24739304	MGI
acts upstream of or within single fertilization	IGI IGI: Inferred from genetic interaction	24739304	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	9420335	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	24739304	MGI
acts upstream of or within tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	9420335	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18692037	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18212064	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16330325	MGI
acts upstream of or within uterus development	IGI IGI: Inferred from genetic interaction	24739304	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16151019	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19366691	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14691138	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12543979	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	9288972	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mothers against decapentaplegic homolog 4	MAD homolog 4 deletion target in pancreatic carcinoma 4 homolog mothers against DPP homolog 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149414	MY-673		98.60%	Unkown
HY-RS13395	SMAD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11223	CMF9	Inhibitor	98.65%	Unkown
HY-179228	AN02		/	Unkown
HY-RS17346	Smad4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23800	Smad4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad4	NCBI	NCBI:4089