RAP1GAP2 - RAP1 GTPase activating protein 2 Gene

Also Known as GARNL4; RAP1GA3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23108

About RAP1GAP2

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,755,645-3,037,741 (from NCBI)

This gene has 11 transcripts (splice variants), 314 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 11.5), bone marrow (RPKM 10.7) and 24 other tissues.

Summary

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RAP1GAP2 Products (5)

mRNA Protein Name
NM_001100398.2 NP_001093868.1 rap1 GTPase-activating protein 2 isoform 2
NM_001330058.2 NP_001316987.1 rap1 GTPase-activating protein 2 isoform 3
NM_001411048.1 NP_001397977.1 rap1 GTPase-activating protein 2 isoform 4
NM_001411049.1 NP_001397978.1 rap1 GTPase-activating protein 2 isoform 5
NM_015085.5 NP_055900.4 rap1 GTPase-activating protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity EXP
EXP: Inferred from Experiment
16076873 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24284068 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
24284068 GOA
involved in regulation of cell size IMP
IMP: Inferred from mutant phenotype
24284068 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in plasma membrane IGI
IGI: Inferred from genetic interaction
24284068 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1GAP2 Protein Structure

Rap_GAP

Rap_GAP: Rap/ran-GAP (278 - 464)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

rap1 GTPase-activating protein 2

  • GTPase activating RANGAP domain-like 4

RAP1GAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAP1GAP2 Q684P5 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RAP1GAP2 Q684P5 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
RAP1GAP2 Q684P5 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11655 RAP1GAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22068 Rap1gap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28586 Rap1gap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RAP1GAP2 VGNC VGNC:45342
Bos taurus RAP1GAP2 VGNC VGNC:33717
Macaca mulatta RAP1GAP2 VGNC VGNC:76561
Felis catus RAP1GAP2 VGNC VGNC:64490
Rattus norvegicus RAP1GAP2 RGD RGD:1304590
Mus musculus RAP1GAP2 MGD MGI:3028623
Others RAP1GAP2 NCBI