ITGA9 - integrin subunit alpha 9 Gene

Also Known as RLC; ITGA4L; ALPHA-RLC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3680

About ITGA9

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,452,141-37,823,507 (from NCBI)

This gene has 4 transcripts (splice variants), 237 orthologues and 17 paralogues. Ubiquitous expression in thyroid (RPKM 11.9), spleen (RPKM 11.4) and 24 other tissues.

Summary

This gene encodes an alpha Integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an Integrin that is a receptor for VCAM1, cytotactin and Osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]

ITGA9 Products (1)

mRNA Protein Name
NM_002207.3 NP_002198.2 integrin alpha-9 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35802072 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
21060781 GOA
involved in negative regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
35802072 GOA
Cellular Component GO Annotation Evidence References Source
part of integrin alpha9-beta1 complex IPI
IPI: Inferred from physical interaction
25748048 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA9 Protein Structure

VCBS

VCBS: Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella (312 - 383)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (459 - 897)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1035 a.a.
Protein Preferred Names Protein Names

integrin alpha-9

  • integrin alpha-RLC

ITGA9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81915 Integrin alpha 9 Antibody (YA1660) WB, IHC-P Human, Mouse, Rat
HY-P81915A Integrin alpha 9 Antibody (YA1660)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Chylothorax, Congenital

  • Congenital Chylothorax

  • Hydrothorax, Congenital
Hereditary Lymphedema Ia

  • Lmph1a

  • Lymphedema, Hereditary, Ia

  • Milroy Disease
Lynch Syndrome

  • Hereditary Nonpolyposis Colon Cancer

  • Hereditary Nonpolyposis Colorectal Cancer

  • Hereditary Nonpolyposis Colorectal Carcinoma

  • Hereditary Nonpolyposis Colorectal Neoplasms

  • Familial Nonpolyposis Colon Cancer

  • Hnpcc

  • Coca 1

  • Hereditary Defective Mismatch Repair Syndrome

  • Hereditary Non-Polyposis Colon Cancer

  • Hereditary Non-Polyposis Colon Cancer Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer

  • Hereditary Non-Polyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colon Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Neoplasm

  • Hnpcc - Hereditary Nonpolyposis Colon Cancer

  • Cancer Family Syndrome

  • Familial Nonpolyposis Colorectal Cancer

  • Colon Cancer, Familial Nonpolyposis

  • Colorectal Neoplasms, Hereditary Nonpolyposis

  • Cancer, Colorectal, Nonpolyposis, Hereditary

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Lymphedema-Distichiasis Syndrome

  • Lymphedema With Distichiasis

  • Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus

  • LPHDST

  • Distichiasis-Lymphedema Syndrome

  • Lymphedema Distichiasis Syndrome

  • Hereditary Lymphedema-Distichiasis Syndrome

  • Lymphedema Distichiasis
Hypotrichosis-Lymphedema-Telangiectasia Syndrome

  • HLTS

  • Hypotrichosis Lymphedema Telangiectasia Syndrome

  • Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

  • Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Yellow Nail Syndrome

  • Yns

  • Lymphedema And Yellow Nails

  • Lymphedema With Yellow Nails

  • Lymphedema-Yellow Nails

  • LYYN

  • Hereditary Lymphedema And Yellow Nails

  • Hereditary Lymphoedema And Yellow Nails
Hereditary Lymphedema

  • Milroy Disease
Hereditary Lymphedema I

  • Lymphedema

  • Hereditary Lymphedema Type I

  • Congenital Primary Lymphedema

  • Lmph1

  • Milroy Disease

  • Nonne-Milroy Lymphedema

  • Pcl

  • Lymphedema Hereditary Type 1
Hennekam Syndrome

  • Hennekam Lymphangiectasia Lymphedema Syndrome

  • Hennekam Lymphangiectasia-Lymphedema Syndrome

  • Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome

  • Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome

  • Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome

  • Lymphangiectasies And Lymphedema Hennekam Type

  • Generalized Lymphatic Dysplasia

  • Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16307 MB05032 Inhibitor 99.63% Unkown
HY-RS06956 ITGA9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ITGA9 VGNC VGNC:97469
Bos taurus ITGA9 VGNC VGNC:30320
Canis familiaris ITGA9 VGNC VGNC:49914
Macaca mulatta ITGA9 VGNC VGNC:82165
Rattus norvegicus ITGA9 RGD RGD:1311191
Mus musculus ITGA9 MGD MGI:104756
Others ITGA9 NCBI