DPF1 - double PHD fingers 1 Gene

Also Known as NEUD4; BAF45b; SMARCG1; neuro-d4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8193

About DPF1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,211,006-38,229,695 (from NCBI)

This gene has 19 transcripts (splice variants), 191 orthologues and 9 paralogues. Biased expression in brain (RPKM 6.5) and testis (RPKM 0.6).

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; nervous system development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of nBAF complex. [provided by Alliance of Genome Resources, Apr 2022]

DPF1 Products (5)

mRNA	Protein	Name
NM_001135155.3	NP_001128627.2	zinc finger protein neuro-d4 isoform a
NM_001135156.3	NP_001128628.1	zinc finger protein neuro-d4 isoform c
NM_001289978.2	NP_001276907.2	zinc finger protein neuro-d4 isoform d
NM_001363579.1	NP_001350508.1	zinc finger protein neuro-d4 isoform e
NM_004647.4	NP_004638.3	zinc finger protein neuro-d4 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPF1 Protein Structure

Requiem_N

PHD

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
zinc finger protein neuro-d4	BRG1-associated factor 45B

Related Diseases

Diseases	Alias
Clark-Baraitser Syndrome	CLABARS Baraitser Syndrome Autosomal Dominant Intellectual Disability 49 Mental Retardation, Autosomal Dominant 49, Formerly Mrd49, Formerly Intellectual Developmental Disorder, Autosomal Dominant 49 Autosomal Dominant Mental Retardation 49 Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features Mrd49 Progeria Short Stature Pigmented Nevi
Small-Cell Carcinoma Of The Ovary Of Hypercalcemic Type	Hypercalcemic Type Ovarian Small Cell Carcinoma Small Cell Carcinoma Of The Ovary, Hypercalcemic Type Ovarian Small Cell Carcinoma, Hypercalcemic Type
Autosomal Dominant Intellectual Developmental Disorder	Autosomal Dominant Mental Retardation Autosomal Dominant Non-Syndromic Mental Retardation Autosomal Dominant Non-Syndromic Intellectual Disability Mental Retardation, Autosomal Dominant
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03949	DPF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22146	Dpf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28667	Dpf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DPF1	VGNC	VGNC:40065
Bos taurus	DPF1	VGNC	VGNC:28175
Macaca mulatta	DPF1	VGNC	VGNC:71869
Rattus norvegicus	DPF1	RGD	RGD:61868
Felis catus	DPF1	VGNC	VGNC:61594
Mus musculus	DPF1	MGD	MGI:1352748
Others	DPF1	NCBI