EMILIN2 - elastin microfibril interfacer 2 Gene

Also Known as FOAP-10; EMILIN-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84034

About EMILIN2

Cytogenetic location: 18p11.32-p11.31 Genomic coordinates (GRCh38): 18:2,846,232-2,916,003 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues and 4 paralogues. Broad expression in placenta (RPKM 19.1), appendix (RPKM 17.1) and 22 other tissues.

Summary

Predicted to enable extracellular matrix constituent conferring elasticity. Predicted to be involved in cell adhesion. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

EMILIN2 Products (1)

mRNA Protein Name
NM_032048.3 NP_114437.2 EMILIN-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11278945 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
24374807 GOA
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
20360940 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
24374807 GOA
involved in positive regulation of defense response to bacterium IDA
IDA: Inferred from direct assay
17988845 GOA
involved in positive regulation of platelet aggregation IDA
IDA: Inferred from direct assay
25658937 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
11278945 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMILIN2 Protein Structure

EMI

EMI: EMI domain (45 - 115)

C1q

C1q: C1q domain (908 - 1044)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1053 a.a.
Protein Preferred Names Protein Names

EMILIN-2

  • elastin microfibril interface-located protein 2

Related Diseases

Diseases Alias
Porokeratosis

  • Disseminated Superficial Actinic Porokeratosis

  • Dsap

  • Porokeratosis Of Mibelli

  • Porokeratosis, Disseminated Superficial Actinic

  • Porokeratosis, Disseminated Superficial Actinic, 1
Oropouche Fever

  • Oropouche Virus Disease

  • Oropouche Mosquito-Borne Viral Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04351 EMILIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21236 Emilin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27753 Emilin2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EMILIN2 RGD RGD:1305343
Felis catus EMILIN2 VGNC VGNC:61846
Canis familiaris EMILIN2 VGNC VGNC:40344
Macaca mulatta EMILIN2 VGNC VGNC:72076
Mus musculus EMILIN2 MGD MGI:2389136
Bos taurus EMILIN2 VGNC VGNC:28474
Others EMILIN2 NCBI