DYRK4 - dual specificity tyrosine phosphorylation regulated kinase 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8798

About DYRK4

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,562,208-4,613,875 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 12 paralogues. Broad expression in testis (RPKM 18.7), thyroid (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

DYRK4 Products (7)

mRNA	Protein	Name
NM_001282285.3	NP_001269214.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 2
NM_001282286.2	NP_001269215.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 3
NM_001371301.2	NP_001358230.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 4
NM_001394779.1	NP_001381708.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 5
NM_001394780.1	NP_001381709.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 6
NM_001407019.1	NP_001393948.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1
NM_003845.3	NP_003836.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK4 Protein Structure

Pkinase

0
100
200
300
400
520 a.a.

Protein Preferred Names	Protein Names
dual specificity tyrosine-phosphorylation-regulated kinase 4	dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4

DYRK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DYRK4	Q9NR20	MID1	Homo sapiens	O15344	Validated Y2H	25416956
Intra	DYRK4	Q9NR20	MID1	Homo sapiens	O15344	Y2H Array	25416956
Intra	DYRK4	Q9NR20	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	DYRK4	Q9NR20	HSP90AA1	Homo sapiens	P07900	Lumier	25036637
Intra	DYRK4	Q9NR20	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	DYRK4	Q9NR20	DYRK2	Homo sapiens	Q92630	BiFC	23602568

Cross: Cross-species interaction Intra: Intraspecies interaction

DYRK4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810092	Dyrk4 Antibody (YA9436)	WB, IP	human

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7
Abdominal Obesity-Metabolic Syndrome 3	AOMS3 Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease Obesity, Abdominal, Metabolic Syndrome, Type 3
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2	Abdominal Obesity-Metabolic Syndrome Abdominal Obesity Metabolic Syndrome Metabolic Syndrome X Aoms2 Aoms1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117049	Leucettine L41	Inhibitor	98.98%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-162750	ZJCK-6-46	Inhibitor	99.06%	Unkown
HY-402805A	DYRK2-IN-2 hydrochloride	Inhibitor	/	Unkown
HY-402805	DYRK2-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYRK4	MGD	MGI:1330292
Macaca mulatta	DYRK4	VGNC	VGNC:97761
Bos taurus	DYRK4	VGNC	VGNC:55903
Felis catus	DYRK4	VGNC	VGNC:83870
Rattus norvegicus	DYRK4	RGD	RGD:1306800
Others	DYRK4	NCBI