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FMNL3 - formin like 3 Gene

Also Known as FRL2; WBP3; FHOD3; WBP-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91010

About FMNL3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,636,499-49,707,405 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 8.1), testis (RPKM 7.5) and 25 other tissues.

Summary

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

FMNL3 Products (3)

mRNA	Protein	Name
NM_001367835.1	NP_001354764.1	formin-like protein 3 isoform 3
NM_175736.5	NP_783863.4	formin-like protein 3 isoform 1
NM_198900.3	NP_944489.2	formin-like protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24223803	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in filopodium assembly	IDA IDA: Inferred from direct assay	24223803	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	21834987	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21834987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMNL3 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1027 a.a.

Protein Preferred Names	Protein Names
formin-like protein 3	WW domain binding protein 3

Related Diseases

Diseases	Alias
Malignant Breast Melanoma	Malignant Melanoma Of Breast Breast Melanoma
Cerebral Amyloid Angiopathy, Itm2b-Related, 2	Dementia, Familial Danish Fdd Familial Danish Dementia Heredopathia Ophthalmootoencephalica Hooe Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis Adan Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy 2 Itm2b Amyloidosis Familial Cerebral Amyloid Angiopathy Itm2b-Related Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy Familial Dementia, Danish Type Cerebral Amyloid Angiopathy, Itm2b-Related 2 CAA-ITM2B2 Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis Dementia, Familial, Danish

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05004	FMNL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20410	Fmnl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26919	Fmnl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FMNL3	RGD	RGD:1583854
Canis familiaris	FMNL3	VGNC	VGNC:40915
Bos taurus	FMNL3	VGNC	VGNC:29048
Mus musculus	FMNL3	MGD	MGI:109569
Macaca mulatta	FMNL3	VGNC	VGNC:72560
Felis catus	FMNL3	VGNC	VGNC:62306
Others	FMNL3	NCBI