SLC23A2 - solute carrier family 23 member 2 Gene

Also Known as NBTL1; SVCT2; YSPL2; SLC23A1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9962

About SLC23A2

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,852,358-5,010,313 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 2 paralogues. Broad expression in adrenal (RPKM 40.7), brain (RPKM 20.8) and 23 other tissues.

Summary

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]

SLC23A2 Products (2)

mRNA Protein Name
NM_005116.6 NP_005107.4 solute carrier family 23 member 2
NM_203327.2 NP_976072.1 solute carrier family 23 member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-ascorbate:sodium symporter activity IDA
IDA: Inferred from direct assay
10471399 GOA
enables L-ascorbic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
10471399 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
34673103 GOA
Biological Process GO Annotation Evidence References Source
involved in L-ascorbic acid transmembrane transport IDA
IDA: Inferred from direct assay
10471399 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18417304 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15993839 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10631088 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 23 member 2

  • Na(+)/L-ascorbic acid transporter 2

Related Diseases

Diseases Alias
Hypoascorbemia

  • Scurvy

  • Ascorbic Acid Deficiency

  • Vitamin C Deficiency

  • Vitamin C, Inability To Synthesize

  • Deficiency Of Vitamin C

  • Scorbutus

  • Vitamin C
Micronodular Basal Cell Carcinoma

  • Skin Micronodular Basal Cell Carcinoma

  • Basal Cell Carcinoma, Micronodular
Hemophagocytic Lymphohistiocytosis, Familial, 2

  • Familial Hemophagocytic Lymphohistiocytosis 2

  • FHL2

  • Hplh2

  • Hlh2

  • Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13081 SLC23A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13082 SLC23A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC23A2 VGNC VGNC:98446
Rattus norvegicus SLC23A2 RGD RGD:619876
Felis catus SLC23A2 VGNC VGNC:65248
Canis familiaris SLC23A2 VGNC VGNC:46283
Mus musculus SLC23A2 MGD MGI:1859682
Bos taurus SLC23A2 VGNC VGNC:34734
Others SLC23A2 NCBI